Target Details
| UniProt AC | P21802 |
|---|---|
| Gene Symbol | FGFR2 |
| Protein Name | Fibroblast growth factor receptor 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07679 (I-set) PF13927 (Ig_3) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 2,130
- Clinical molecules 64
- Avg pChEMBL 7.82
KEGG Pathways (13)
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- Gastric cancer
- MAPK signaling pathway
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
Associated Diseases (12)
- Antley-Bixler syndrome
- Apert syndrome
- Beare-Stevenson syndrome
- Bent bone dysplasia syndrome
- Crouzon syndrome
- Gastric cancer
- Jackson-Weiss syndrome
- Lacrimo-auriculo-dento-digital syndrome
- Pfeiffer syndrome
- Saethre-Chotzen syndrome
- Scaphocephaly, maxillary retrusion, and impaired intellectual development
- Syndromic craniosynostoses
Active Molecules (2,130)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KWSRBEPOLXYHOX
|
7.5 | IC50 | 4 | — | |
PGRWVLHMKFTXIP
|
7.5 | IC50 | 2 | — | |
QHWNOTNFJRKXDT
|
7.5 | IC50 | 4 | — | |
XWVUDSIMQJXHSZ
|
7.5 | IC50 | 2 | — | |
ZKZXKZYRLOFSOJ
|
7.5 | IC50 | 3 | — | |
LARHWOZUTTUWPB
|
7.5 | IC50 | 3 | — | |
UJNSYJXIQWRZLK
|
7.5 | IC50 | 3 | — | |
VAARYSWULJUGST
|
7.5 | Kd | 119 | Yes | |
XJSLPSJVSNHJJL
|
7.5 | IC50 | 3 | — | |
XRXNDGMCQAAXTI
|
7.5 | IC50 | 3 | — | |
NDEFXZOKPREYOV
|
7.5 | IC50 | 9 | — | |
QANHPRIWWFSGTM
|
7.5 | IC50 | 4 | — | |
QCGVVQQTVSMBOE
|
7.5 | IC50 | 2 | — | |
QIASHDRGDBMNGW
|
7.5 | IC50 | 6 | — | |
UBLLKTCSEZOWKU
|
7.5 | IC50 | 5 | — | |
XHBNHAFKLFDKSG
|
7.5 | IC50 | 5 | — | |
YRQNKOIBSDPYQD
|
7.5 | IC50 | 3 | — | |
GBUHYEIUDCVWCP
|
7.5 | IC50 | 5 | — | |
SSNCGXCONZGQSY
|
7.5 | IC50 | 4 | — | |
GCTRVFZGBTUDPW
|
7.5 | IC50 | 7 | Yes | |
JLXBHBVYBGZIEY
|
7.5 | IC50 | 7 | Yes | |
RLRHANAAZMONDJ
|
7.5 | IC50 | 3 | — | |
SGGQDZVXANNRTL
|
7.5 | IC50 | 3 | — | |
WGWDCACWYPRSFY
|
7.5 | IC50 | 5 | — | |
WQZQCVQJRSEWLU
|
7.5 | IC50 | 5 | — | |
XMVPNQMHPNXSPG
|
7.5 | IC50 | 2 | — | |
GYZQEGDUEZWDMT
|
7.5 | IC50 | 4 | — | |
HTCPNTMZIFPYSY
|
7.5 | IC50 | 4 | — | |
KSWZVURHYKWKHC
|
7.5 | IC50 | 5 | — | |
MIGRDHVJFBYULX
|
7.5 | IC50 | 3 | — | |
OSUOMNGUILCJQE
|
7.5 | IC50 | 3 | — | |
WHVXBHTZGZQBQC
|
7.5 | IC50 | 5 | — | |
YIENCCLQQGIORJ
|
7.5 | IC50 | 2 | — | |
CGBKLNITKCQKHO
|
7.5 | IC50 | 2 | — | |
HJJZFNYKBWSNHU
|
7.5 | IC50 | 2 | — | |
XXJWYDDUDKYVKI
|
7.5 | Kd | 52 | — | |
DHTQWWBETFUIRD
|
7.5 | IC50 | 3 | — | |
FQQPROZCOUSSJP
|
7.4 | IC50 | 7 | — | |
HHAMLGNIKIGSCW
|
7.4 | IC50 | 5 | — | |
UZJUXSBJDWBORI
|
7.4 | IC50 | 3 | — | |
VIZZPQWXNSJIDP
|
7.4 | IC50 | 3 | — | |
NDEFXZOKPREYOV
|
7.4 | IC50 | 8 | — | |
OKTZBKLVRWLMBJ
|
7.4 | IC50 | 4 | — | |
QTURBRSPQSBVKB
|
7.4 | IC50 | 3 | — | |
UNSUYJXQOBXBNF
|
7.4 | IC50 | 5 | — | |
XZXHXSATPCNXJR
|
7.4 | IC50 | 165 | Yes | |
AFGXVTXVCTUMNA
|
7.4 | IC50 | 3 | — | |
ANCOKRUUPIESLN
|
7.4 | IC50 | 3 | — | |
HUMTUHRIAKUTLM
|
7.4 | IC50 | 5 | — | |
JFNNPQNEIJFJLP
|
7.4 | IC50 | 3 | — |