Target Details
| UniProt AC | P19838 |
|---|---|
| Gene Symbol | NFKB1 |
| Protein Name | Nuclear factor NF-kappa-B p105 subunit |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF12796 (Ank_2) PF00531 (Death) PF16179 (RHD_dimer) PF00554 (RHD_DNA_bind) |
Summary
- Multi-target molecules 140
- Clinical molecules 0
- Avg pChEMBL 6.96
KEGG Pathways (77)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Amoebiasis
- Antifolate resistance
- Apoptosis
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Cocaine addiction
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Diabetic cardiomyopathy
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Inflammatory bowel disease
- Influenza A
- Insulin resistance
- Kaposi sarcoma-associated herpesvirus infection
- Legionellosis
- Leishmaniasis
- Lipid and atherosclerosis
- Longevity regulating pathway
- MAPK signaling pathway
- Measles
- MicroRNAs in cancer
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prolactin signaling pathway
- Prostate cancer
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Transcriptional misregulation in cancer
- Tuberculosis
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
Associated Diseases (1)
Active Molecules (140)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HMXLOKAIIPOWQP
|
6.4 | IC50 | 3 | — | |
BFANKIPRJRXYSS
|
6.4 | IC50 | 4 | — | |
ODRMXBSDOYWKNE
|
6.4 | IC50 | 4 | — | |
UNFFMUXRKGUXDB
|
6.4 | IC50 | 4 | — | |
XYBIZGOXEPWEFZ
|
6.4 | IC50 | 5 | — | |
ZMCDRZWLPJBCJA
|
6.4 | IC50 | 4 | — | |
KTEXNACQROZXEV
|
6.3 | IC50 | 4 | — | |
PHBPDHFIJFLEGD
|
6.3 | IC50 | 3 | — | |
XLPMOKAMOKNAMA
|
6.3 | IC50 | 3 | — | |
ASCOWQDAVUCWHH
|
6.3 | IC50 | 4 | — | |
DDFXQPHXKWGYEZ
|
6.3 | IC50 | 4 | — | |
NLRGWKVQZPYNNM
|
6.3 | IC50 | 2 | — | |
KHEXXENPPWDAHU
|
6.2 | IC50 | 4 | — | |
ULKJBEWLFAYGPT
|
6.2 | IC50 | 4 | — | |
XVXKDOBLGHCVLT
|
6.2 | IC50 | 2 | — | |
LTIPKVHQIFLZGQ
|
6.2 | IC50 | 3 | — | |
ZCCPLJOKGAACRT
|
6.2 | Kd | 599 | — | |
BFUXXUCYXDKBGL
|
6.2 | IC50 | 5 | — | |
DSYPQICAGKUAFT
|
6.2 | IC50 | 5 | — | |
XOHKOCNFVBVEEY
|
6.2 | IC50 | 5 | — | |
CJFLBULDBHDVQT
|
6.1 | IC50 | 3 | — | |
RHBTWDFORLRVLM
|
6.1 | IC50 | 4 | — | |
VJBLSDVEUIUMEE
|
6.1 | IC50 | 2 | — | |
XYMYOQHYWDKQLT
|
6.1 | IC50 | 4 | — | |
TUKFOKSFXYYBDV
|
6.1 | IC50 | 3 | — | |
JHPYMNZPMYYRPA
|
6.1 | IC50 | 4 | — | |
PNSAXLUIESEAGV
|
6.1 | IC50 | 3 | — | |
ZIWQBCKDJZBDIR
|
6.1 | IC50 | 5 | — | |
OHMJOYZRJHYMAE
|
6.0 | IC50 | 4 | — | |
QRVJINBBPOWTHS
|
6.0 | IC50 | 5 | — | |
SVKUGLALKUKGHJ
|
6.0 | IC50 | 2 | — | |
DVTZXBWRHRFDEE
|
6.0 | IC50 | 3 | — | |
KGDSZCYQRYDCCF
|
6.0 | IC50 | 3 | — | |
KNMXOBLXBVMAIQ
|
6.0 | IC50 | 4 | — | |
BJFLQQFMBZHWKK
|
6.0 | IC50 | 3 | — | |
JWIIKHRJOUQCQG
|
6.0 | IC50 | 5 | — | |
KBGATAWDHCZFQR
|
6.0 | IC50 | 5 | — | |
MMSKFTCJMPJSON
|
6.0 | IC50 | 5 | — | |
YHCPTBQDJKEVNL
|
6.0 | IC50 | 5 | — | |
YZVLYVMNCAIILW
|
6.0 | IC50 | 5 | — |