Target Details
| UniProt AC | P19438 |
|---|---|
| Gene Symbol | TNFRSF1A |
| Protein Name | Tumor necrosis factor receptor superfamily member 1A |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00531 (Death) PF00020 (TNFR_c6) |
Summary
- Multi-target molecules 2
- Clinical molecules 0
- Avg pChEMBL 6.05
KEGG Pathways (35)
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Amyotrophic lateral sclerosis
- Apoptosis
- Apoptosis - multiple species
- Chagas disease
- Coronavirus disease - COVID-19
- Cytokine-cytokine receptor interaction
- Fluid shear stress and atherosclerosis
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin resistance
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- NF-kappa B signaling pathway
- Necroptosis
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- TNF signaling pathway
- Toxoplasmosis
- Tuberculosis
- Viral protein interaction with cytokine and cytokine receptor
- mTOR signaling pathway
Associated Diseases (2)
Active Molecules (2)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
BMBIKZHGTPMMMM
|
6.1 | IC50 | 14 | — | |
XWCNNWPTHCJOSC
|
6.0 | Kd | 2 | — |