Target Details
| UniProt AC | P19174 |
|---|---|
| Gene Symbol | PLCG1 |
| Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00168 (C2) PF23329 (EF_HAND_1_PLCG) PF23583 (EF_HAND_2_PLCG) PF00169 (PH) PF00388 (PI-PLC-X) PF00387 (PI-PLC-Y) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 2
- Clinical molecules 0
- Avg pChEMBL 6.5
KEGG Pathways (46)
- AGE-RAGE signaling pathway in diabetic complications
- Axon guidance
- Calcium signaling pathway
- Chemokine signaling pathway
- Choline metabolism in cancer
- Coronavirus disease - COVID-19
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Glioma
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatocellular carcinoma
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Inositol phosphate metabolism
- Kaposi sarcoma-associated herpesvirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Metabolic pathways
- MicroRNAs in cancer
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Shigellosis
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thyroid hormone signaling pathway
- VEGF signaling pathway
- Vibrio cholerae infection
- Yersinia infection
Associated Diseases (1)
Top Co-occurrence Targets
- ITK 2 shared
Active Molecules (2)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DOBZFSQNBHNUFD
|
6.7 | IC50 | 2 | — | |
GALDZRYXDQCYKT
|
6.3 | IC50 | 2 | — |