Target Details
| UniProt AC | P18084 |
|---|---|
| Gene Symbol | ITGB5 |
| Protein Name | Integrin beta-5 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF23105 (EGF_integrin) PF18372 (I-EGF_1) PF08725 (Integrin_b_cyt) PF07965 (Integrin_B_tail) PF00362 (Integrin_beta) PF17205 (PSI_integrin) |
Summary
- Multi-target molecules 402
- Clinical molecules 0
- Avg pChEMBL 7.8
KEGG Pathways (13)
- Arrhythmogenic right ventricular cardiomyopathy
- Cytoskeleton in muscle cells
- Dilated cardiomyopathy
- ECM-receptor interaction
- Efferocytosis
- Focal adhesion
- Human papillomavirus infection
- Hypertrophic cardiomyopathy
- Integrin signaling
- PI3K-Akt signaling pathway
- Phagosome
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
Active Molecules (402)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DOCHXGULTZHKAZ
|
10.0 | IC50 | 4 | — | |
MFCABRSSOZYCRL
|
10.0 | IC50 | 8 | — | |
PEFBVOAICYLSAF
|
10.0 | IC50 | 8 | — | |
SHRSEUHJTZQLRO
|
10.0 | IC50 | 8 | — | |
BZWRHPJFRPTNKG
|
9.8 | IC50 | 2 | — | |
IYUQNBTYGGJEAT
|
9.8 | IC50 | 3 | — | |
BCDVKMOAMMODMM
|
9.7 | IC50 | 4 | — | |
BWAUVRFZNDRMLY
|
9.7 | IC50 | 8 | — | |
GDEQKRGKHZOXGD
|
9.7 | IC50 | 8 | — | |
QTBFGJFGHGTDRF
|
9.7 | IC50 | 8 | — | |
RTYLRDWEJUNBLU
|
9.7 | IC50 | 8 | — | |
NNOYJUNBGWLDGM
|
9.7 | IC50 | 3 | — | |
JXVVEFIKDDVLOS
|
9.5 | IC50 | 8 | — | |
OBOJFQICXTYCRY
|
9.5 | IC50 | 8 | — | |
XGZVUDGXURHWEC
|
9.5 | IC50 | 3 | — | |
ZAMKDPACDNUZPJ
|
9.5 | IC50 | 8 | — | |
JANXNGXRGZTCLF
|
9.5 | IC50 | 3 | — | |
PMZKPKOPQCGFFU
|
9.5 | IC50 | 2 | — | |
WUEFOEAIDROUBP
|
9.4 | IC50 | 3 | — | |
XCOSALUIMNYBMA
|
9.4 | IC50 | 2 | — | |
BLKCXKZUJXHCGP
|
9.4 | IC50 | 4 | — | |
SMMNOJYHMMCWQP
|
9.4 | IC50 | 5 | — | |
CJFKBQRLRONQOT
|
9.4 | IC50 | 7 | — | |
CJRDXSVCUSRJDR
|
9.4 | IC50 | 8 | — | |
RBJQMIIPTLTYFP
|
9.4 | IC50 | 8 | — | |
UCBYYQWMMNUSGH
|
9.4 | IC50 | 8 | — | |
YPAMHQMVIMQKOR
|
9.4 | IC50 | 8 | — | |
QPZOEIQRDYCGMD
|
9.4 | IC50 | 5 | — | |
FVYSXFUNKAIEAQ
|
9.3 | IC50 | 3 | — | |
HIKDGFUZLZJZCB
|
9.3 | IC50 | 8 | — | |
RQMPMSIEFFKLGD
|
9.3 | IC50 | 3 | — | |
BQYBIJDRTDZCAJ
|
9.2 | IC50 | 8 | — | |
XRXSSPOFDFFALK
|
9.2 | IC50 | 8 | — | |
GNIPEZAXNSJOFR
|
9.2 | IC50 | 3 | — | |
MYCBMOUNZVUWNJ
|
9.2 | IC50 | 2 | — | |
BEOOWKDNVJKISL
|
9.2 | IC50 | 3 | — | |
LIFIBSDQAZPDID
|
9.2 | IC50 | 4 | — | |
LTHXCHXVFSNDKJ
|
9.1 | IC50 | 3 | — | |
PQFLZAWKXDKTMD
|
9.1 | IC50 | 2 | — | |
BYVFLADXGMTEEK
|
9.1 | IC50 | 2 | — | |
MJIZYHGNHUTXIR
|
9.1 | IC50 | 3 | — | |
XNBNFFZMGGWODG
|
9.1 | IC50 | 4 | — | |
XOCAITJQZBYGFQ
|
9.1 | IC50 | 5 | — | |
YTAHOLPCQRGOAW
|
9.1 | IC50 | 5 | — | |
SLTMEZLQPRTTBL
|
9.1 | IC50 | 3 | — | |
VYTWTVISEPFYEI
|
9.1 | IC50 | 2 | — | |
BIAYEWRLSABXRF
|
9.1 | IC50 | 3 | — | |
HAVKADYFCFXNIM
|
9.1 | IC50 | 4 | — | |
HXARURWAKJJNNF
|
9.1 | IC50 | 3 | — | |
LTTIHWWYCLBIKC
|
9.1 | IC50 | 3 | — |