Target Details
| UniProt AC | P17612 |
|---|---|
| Gene Symbol | PRKACA |
| Protein Name | cAMP-dependent protein kinase catalytic subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 453
- Clinical molecules 52
- Avg pChEMBL 6.97
KEGG Pathways (72)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy - animal
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Neuroactive ligand signaling
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin-regulated water reabsorption
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (4)
Active Molecules (453)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
BRTHUECZMVKNMQ
|
6.1 | Ki | 31 | — | |
BTHLNBWTKKAULX
|
6.1 | Ki | 16 | — | |
HZPACYSNLOCDLW
|
6.1 | Ki | 48 | — | |
JEFRBITWIOXMNQ
|
6.1 | IC50 | 6 | — | |
KVYKDXMRLMPSGQ
|
6.1 | Ki | 7 | — | |
MADCXGNPDBWPLM
|
6.1 | Ki | 25 | — | |
NVRXTLZYXZNATH
|
6.1 | Ki | 47 | Yes | |
PROLIXHVRCJEFH
|
6.1 | Ki | 46 | — | |
QEWSTOOMTBAUAG
|
6.1 | Ki | 17 | — | |
SKLNUYVBOFIJAT
|
6.1 | Ki | 5 | — | |
UIRCQOKSJDLYBB
|
6.1 | Ki | 50 | — | |
UQFRSHRWRKYNDE
|
6.1 | Ki | 17 | Yes | |
UTFXYGYVDDLJER
|
6.1 | Ki | 36 | — | |
VOXXNSOMSGHJJR
|
6.1 | Ki | 3 | — | |
VYACUCWGDYRIAG
|
6.1 | Ki | 7 | — | |
WONUEZVTDVQBDC
|
6.1 | Ki | 7 | — | |
XYUFCXJZFZPEJD
|
6.1 | IC50 | 9 | — | |
JMYQFLAMZXRYGY
|
6.1 | IC50 | 6 | Yes | |
PMXKUMCLYSFPJB
|
6.1 | IC50 | 4 | — | |
CWFBWCJRVBRKPQ
|
6.1 | Ki | 2 | — | |
YPDLMDMBCACZDE
|
6.1 | IC50 | 8 | Yes | |
CSGQVNMSRKWUSH
|
6.0 | Kd | 21 | — | |
AYCPARAPKDAOEN
|
6.0 | Kd | 73 | — | |
QYEKPILGAVXHQH
|
6.0 | IC50 | 5 | — | |
VGRBFVDNFGSMNW
|
6.0 | IC50 | 3 | — | |
HCRQPXYLXXLKPT
|
6.0 | Ki | 5 | — | |
PHEMXOLLNFYYLK
|
6.0 | IC50 | 8 | Yes | |
AQKQATGZIKRZMQ
|
6.0 | Ki | 16 | — | |
ASNQMAVHHGGQRB
|
6.0 | Ki | 14 | — | |
GDYZFFBMSBDTAA
|
6.0 | Ki | 60 | — | |
GGQAEINRBKFRGZ
|
6.0 | IC50 | 15 | Yes | |
IFPPYSWJNWHOLQ
|
6.0 | Ki | 52 | Yes | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
JJGSOVIZOMZMCS
|
6.0 | Ki | 35 | — | |
KBDRSPRFXNCQAM
|
6.0 | Ki | 8 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
LSZUFMXSTJOZFE
|
6.0 | Ki | 9 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — | |
OBHMNLIBIPFXCY
|
6.0 | Ki | 15 | — | |
PMXPVPGZZRMXIV
|
6.0 | Ki | 8 | — | |
QBKUOOQFSVMDPB
|
6.0 | Ki | 31 | — | |
QHKYPYXTTXKZST
|
6.0 | Ki | 28 | — | |
QVWKRMXAYICTFS
|
6.0 | Ki | 8 | — | |
UCLBDUZAAUTHBW
|
6.0 | Ki | 4 | — | |
VBPYLWZBNRFLEM
|
6.0 | IC50 | 4 | — | |
WGYAMRMJVUNILQ
|
6.0 | Ki | 3 | — | |
XTVULKIROSNNTG
|
6.0 | Ki | 29 | — | |
XZZUBMJMGJRIKY
|
6.0 | Ki | 4 | — | |
YJBNTRQKJQHMTM
|
6.0 | Ki | 11 | — | |
YMIJUBCSOKSFRU
|
6.0 | Ki | 87 | — |