Target Details
| UniProt AC | P17612 |
|---|---|
| Gene Symbol | PRKACA |
| Protein Name | cAMP-dependent protein kinase catalytic subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 453
- Clinical molecules 52
- Avg pChEMBL 6.97
KEGG Pathways (72)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy - animal
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Neuroactive ligand signaling
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin-regulated water reabsorption
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (4)
Active Molecules (453)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QRCXMLQLNQMAFC
|
6.3 | Ki | 10 | — | |
QVNZKVACBBTKSL
|
6.3 | Ki | 38 | — | |
SODGZPDNROVASD
|
6.3 | Ki | 7 | — | |
VNDWQCSOSCCWIP
|
6.3 | Ki | 39 | Yes | |
ZGDYBJXDIXVTLV
|
6.3 | Ki | 54 | — | |
ZGZVRPRSFXRGCF
|
6.3 | Ki | 76 | — | |
ZVWRFVCNQOECJS
|
6.3 | Ki | 71 | — | |
KEWARFUPGHEOFW
|
6.3 | IC50 | 3 | — | |
VPXODNSZPGOPSV
|
6.3 | Ki | 2 | — | |
YOPFBPOFMONRKA
|
6.3 | Ki | 4 | — | |
VNBRGSXVFBYQNN
|
6.3 | IC50 | 22 | Yes | |
ZPMJSCUYKDXFKU
|
6.2 | Ki | 2 | — | |
DFYXXJJSVFEUQI
|
6.2 | Ki | 8 | — | |
BCODCVMBVICQAV
|
6.2 | Ki | 4 | — | |
NHHQJBCNYHBUSI
|
6.2 | Kd | 220 | — | |
PRIKHRTWFXDNDC
|
6.2 | Ki | 3 | — | |
HEESYZLXEJDLJI
|
6.2 | IC50 | 4 | — | |
HJFKANRRGGLIMD
|
6.2 | IC50 | 4 | — | |
PHXJVRSECIGDHY
|
6.2 | IC50 | 59 | — | |
CFBADDSSFSYJPF
|
6.2 | Ki | 23 | — | |
DTMZXHDQZQLTHA
|
6.2 | Ki | 21 | — | |
IJNGXROUMFEKDB
|
6.2 | Ki | 39 | — | |
JNXJKTXDSPWNRP
|
6.2 | Ki | 30 | — | |
KNVOICXEDILAGT
|
6.2 | Ki | 17 | — | |
LWBSSNRDDDFHSH
|
6.2 | Ki | 9 | — | |
MCKPYPWHBUXLEZ
|
6.2 | Ki | 21 | — | |
ONSQVIFJAFIKFZ
|
6.2 | Ki | 6 | — | |
UGUZOLHBLLTLBA
|
6.2 | Ki | 15 | — | |
UOOFSEUSROQBBP
|
6.2 | Ki | 8 | — | |
VEXYJVKMGKPGRV
|
6.2 | Ki | 6 | — | |
WIZFHSAFKKUPRU
|
6.2 | Ki | 5 | — | |
ZCBUQCWBWNUWSU
|
6.2 | Ki | 11 | — | |
ZLHFILGSQDJULK
|
6.2 | Ki | 37 | Yes | |
ZMBDLCDLIZXFHY
|
6.2 | Ki | 9 | — | |
QKKGSTFAKMXWFE
|
6.2 | IC50 | 3 | — | |
KJGUOQMSLKZPAT
|
6.2 | IC50 | 17 | Yes | |
PKQJCYXKRNGUKQ
|
6.2 | IC50 | 6 | — | |
WFRVZENQQASYRN
|
6.2 | IC50 | 2 | — | |
BMGQWWVMWDBQGC
|
6.1 | Kd | 147 | Yes | |
BMGQWWVMWDBQGC
|
6.1 | Kd | 91 | Yes | |
VHQHJGLYTLVYKC
|
6.1 | Ki | 4 | — | |
KJCKVXKGXLPESD
|
6.1 | Ki | 3 | — | |
KJCKVXKGXLPESD
|
6.1 | Ki | 3 | — | |
NRSGWEVTVGZDFC
|
6.1 | IC50 | 50 | — | |
HPBJQOWLAKYNDM
|
6.1 | IC50 | 15 | Yes | |
MQCCJEYZKWZQHU
|
6.1 | IC50 | 15 | Yes | |
BETBNWGUKZUUAX
|
6.1 | IC50 | 21 | — | |
ZTXPZKBYVPEULR
|
6.1 | Ki | 3 | — | |
ATGVCJYHNOSZEV
|
6.1 | Ki | 23 | — | |
BLUHZSPELLCJKH
|
6.1 | Ki | 9 | — |