Target Details
| UniProt AC | P17612 |
|---|---|
| Gene Symbol | PRKACA |
| Protein Name | cAMP-dependent protein kinase catalytic subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 453
- Clinical molecules 52
- Avg pChEMBL 6.97
KEGG Pathways (72)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy - animal
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Neuroactive ligand signaling
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin-regulated water reabsorption
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (4)
Active Molecules (453)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AXRCEOKUDYDWLF
|
6.5 | Kd | 31 | — | |
HSRYETVWRVWJQQ
|
6.5 | IC50 | 6 | — | |
ORWIYCURPDKSBI
|
6.5 | IC50 | 15 | Yes | |
SXLCBECQMMDJSN
|
6.5 | IC50 | 6 | — | |
AWDORCFLUJZUQS
|
6.5 | Ki | 7 | — | |
CLQHLBAJBOQPRR
|
6.5 | IC50 | 3 | — | |
DHYYPPHQZMSVKX
|
6.4 | Ki | 2 | — | |
DRCBMJUPXHWGMN
|
6.4 | IC50 | 15 | Yes | |
SMZYTCQRZVNFFJ
|
6.4 | IC50 | 16 | Yes | |
NEHWSPJUDZLKNN
|
6.4 | IC50 | 4 | — | |
FELQRVDTGNDOSI
|
6.4 | IC50 | 15 | Yes | |
LLDVRUBUBPSOMY
|
6.4 | Ki | 4 | — | |
PZKTZYRRWDJGOH
|
6.4 | IC50 | 5 | — | |
DYGFSCBDKCOJFV
|
6.4 | IC50 | 3 | — | |
JDUBGYFRJFOXQC
|
6.4 | Kd | 13 | — | |
KQGQDDJOYKZFPV
|
6.4 | IC50 | 8 | — | |
MVIAXVXTYFEURX
|
6.4 | IC50 | 3 | — | |
YMUYGRBBEDYUOP
|
6.4 | Ki | 6 | Yes | |
APUCFXHENVUXCY
|
6.4 | Ki | 15 | — | |
BEJGILHFZNTYCX
|
6.4 | Ki | 7 | — | |
DYSRECIVMDGUQU
|
6.4 | Ki | 29 | — | |
GPKQGYSDQQIJLW
|
6.4 | Ki | 19 | — | |
GWXPHWSUMLUDPO
|
6.4 | Ki | 11 | — | |
JMQCXZBXWOIDIO
|
6.4 | Ki | 9 | — | |
MASJMHFQMYAPJR
|
6.4 | Ki | 41 | — | |
MBRVCJRFWYHVHE
|
6.4 | Ki | 9 | — | |
ORUUEFDGYYTXAF
|
6.4 | Ki | 26 | — | |
RKUKAACYUCUJEE
|
6.4 | Ki | 58 | — | |
RWKDVIAVTRRJIR
|
6.4 | Ki | 23 | — | |
SHENEEFOURUIBP
|
6.4 | Ki | 29 | — | |
VIZWJTHWUUQVGO
|
6.4 | Ki | 9 | — | |
WYLVFMBGPRCDQF
|
6.4 | Ki | 14 | — | |
ZKHDDJKHTPLPOQ
|
6.4 | Ki | 62 | — | |
KXPTUMLQPMMHGT
|
6.4 | IC50 | 4 | — | |
FYHDYXSOJZTOJN
|
6.3 | IC50 | 4 | — | |
YLCFOHVAOBLAIK
|
6.3 | IC50 | 14 | — | |
CWFIQHQECWPWQG
|
6.3 | IC50 | 16 | Yes | |
OQSTWXKHTZWKLD
|
6.3 | IC50 | 15 | Yes | |
BZIKSZZVJAQWMC
|
6.3 | Ki | 6 | — | |
APYXQTXFRIDSGE
|
6.3 | IC50 | 4 | — | |
DPEXRCOBPACFOO
|
6.3 | Ki | 36 | — | |
DPPIQOOVRLCHQC
|
6.3 | Ki | 6 | — | |
FHIVNWJIENRJBH
|
6.3 | Ki | 9 | — | |
FRGKMOOHXXLJSE
|
6.3 | Ki | 2 | — | |
GDQXJQSQYMMKRA
|
6.3 | IC50 | 15 | — | |
JIFGOPCFXJIPNK
|
6.3 | Ki | 5 | — | |
LCKDESRGCHSHHO
|
6.3 | Ki | 18 | — | |
MNEBTNXXCJJUOW
|
6.3 | Ki | 7 | — | |
PBBRWFOVCUAONR
|
6.3 | Ki | 26 | Yes | |
PZTHAMCOXITDIY
|
6.3 | IC50 | 5 | — |