Target Details
| UniProt AC | P17612 |
|---|---|
| Gene Symbol | PRKACA |
| Protein Name | cAMP-dependent protein kinase catalytic subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 453
- Clinical molecules 52
- Avg pChEMBL 6.97
KEGG Pathways (72)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy - animal
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Neuroactive ligand signaling
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin-regulated water reabsorption
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (4)
Active Molecules (453)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SVUIYNKSDCANAY
|
6.7 | Ki | 16 | — | |
UDFDIIVNIYWXDM
|
6.7 | Ki | 74 | — | |
VSVWQTDDGQSGHP
|
6.7 | Ki | 51 | — | |
WZSVRUCBLPTNFX
|
6.7 | Ki | 4 | — | |
PYQFQGXOARMGAQ
|
6.7 | IC50 | 11 | — | |
CKJRKRPDNLRZPQ
|
6.7 | IC50 | 7 | — | |
UIARLYUEJFELEN
|
6.7 | Kd | 289 | Yes | |
BXJBYSKTRZASJM
|
6.6 | IC50 | 4 | Yes | |
CKJRKRPDNLRZPQ
|
6.6 | IC50 | 7 | — | |
VAPOMSIOLKMAIW
|
6.6 | Ki | 7 | — | |
NCQQZIOVNVXPQY
|
6.6 | IC50 | 4 | — | |
CALAEFSQWBJMDU
|
6.6 | Ki | 21 | — | |
CLEGDJQQHUTCOW
|
6.6 | Ki | 43 | — | |
DKTMRIORKQEKMU
|
6.6 | Ki | 10 | — | |
GQHMZZXJWGPHDA
|
6.6 | Ki | 20 | — | |
IIRWNGPLJQXWFJ
|
6.6 | IC50 | 4 | — | |
JRLSUZIPUYDUKX
|
6.6 | Ki | 22 | — | |
KBPRRDJOCKWMHQ
|
6.6 | Kd | 2 | — | |
OHPRWVPOPFGLJG
|
6.6 | Ki | 19 | — | |
OWJIKBAZUBPKGN
|
6.6 | IC50 | 7 | — | |
PFCUZXCHLYIMTJ
|
6.6 | Ki | 18 | — | |
PTZQSGFNHIVQKV
|
6.6 | Ki | 8 | — | |
QQWUGDVOUVUTOY
|
6.6 | Ki | 231 | Yes | |
UJBJWYNPUOLFIZ
|
6.6 | Ki | 49 | — | |
UPPGGRZNGRFDAU
|
6.6 | Ki | 21 | — | |
YVKVSKQNYIHXPX
|
6.6 | Ki | 7 | — | |
ZYTFPHRVOZXPGZ
|
6.6 | Ki | 30 | — | |
KSITVHDHIJKJBG
|
6.6 | IC50 | 6 | — | |
GPGZMTPPOHCJRE
|
6.6 | IC50 | 16 | Yes | |
SUTSEXNYUMIAMX
|
6.6 | IC50 | 4 | — | |
IEDDDZFQZKDRBJ
|
6.5 | IC50 | 9 | — | |
ZZSBPGIGIUFJRA
|
6.5 | IC50 | 15 | Yes | |
IZBXLPNFYAKSMH
|
6.5 | Ki | 2 | — | |
AYJBHLUSGLQYDG
|
6.5 | Ki | 16 | — | |
FDBPGAHVEGEARY
|
6.5 | Ki | 19 | — | |
FLEAYYMORDPWAJ
|
6.5 | Ki | 90 | — | |
JLTBOCSFMNSLFH
|
6.5 | Ki | 9 | — | |
JXMYIDZREHNPDO
|
6.5 | Ki | 19 | — | |
KAKGFGCTONHQJW
|
6.5 | Ki | 25 | — | |
MIYRKQLKDQNUKZ
|
6.5 | Ki | 23 | — | |
NOBMKUVHFRVBES
|
6.5 | Ki | 19 | — | |
NPLQZQGAZAUUTB
|
6.5 | Ki | 9 | — | |
NZTPJNIILSLMRH
|
6.5 | IC50 | 7 | — | |
RKDYDLMULRETNX
|
6.5 | Ki | 8 | — | |
VBNPWXWJZJNXEY
|
6.5 | Ki | 18 | Yes | |
VTQQYBGURNVVFE
|
6.5 | Ki | 17 | — | |
WKWGFJFNCXAUEX
|
6.5 | Ki | 14 | Yes | |
XFHCSNRQFQRLHZ
|
6.5 | Ki | 12 | Yes | |
XRAMQMPTFUGPMI
|
6.5 | Ki | 3 | — | |
ZDPGLLQANLROFM
|
6.5 | Ki | 17 | — |