Target Details
| UniProt AC | P17612 |
|---|---|
| Gene Symbol | PRKACA |
| Protein Name | cAMP-dependent protein kinase catalytic subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 453
- Clinical molecules 52
- Avg pChEMBL 6.97
KEGG Pathways (72)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy - animal
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Neuroactive ligand signaling
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin-regulated water reabsorption
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (4)
Active Molecules (453)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OPFXEPWUJYMTBG
|
7.2 | IC50 | 2 | — | |
BQYDGSNDLAZAEW
|
7.2 | Ki | 13 | — | |
CLRFYTGANQZOBS
|
7.2 | Ki | 41 | — | |
FMPKTXNCNJCHCC
|
7.2 | Ki | 25 | — | |
IPKHSYHXXAIZDD
|
7.2 | Ki | 18 | — | |
KTWBYGUSEYSRND
|
7.2 | Ki | 28 | — | |
LACOMQAWPSFXQC
|
7.2 | Ki | 27 | — | |
TVUWQDLBEOZVOU
|
7.2 | Ki | 41 | — | |
XOJQJDHWKVZUAT
|
7.2 | Ki | 9 | — | |
ZDTUVVAJVVQVOT
|
7.2 | IC50 | 4 | — | |
ZRQXCQXWTLVASO
|
7.2 | Ki | 36 | — | |
MYOUXQLHWTWXON
|
7.2 | IC50 | 16 | Yes | |
NEAFSODAYAUEGX
|
7.2 | IC50 | 6 | — | |
XYUFCXJZFZPEJD
|
7.2 | IC50 | 9 | — | |
YIZRPXUMLQCIMQ
|
7.2 | IC50 | 9 | — | |
YIZRPXUMLQCIMQ
|
7.2 | IC50 | 9 | — | |
QXQGSOMQKZFIRY
|
7.2 | IC50 | 10 | — | |
YIZRPXUMLQCIMQ
|
7.2 | IC50 | 7 | — | |
ZKZXNDJNWUTGDK
|
7.1 | IC50 | 9 | — | |
OZPLURSGGRWIKB
|
7.1 | IC50 | 4 | — | |
DFMCXVONDDGQIY
|
7.1 | Ki | 66 | — | |
DWTNLZZEPSCAIH
|
7.1 | Ki | 25 | — | |
LSLPDHNUWRDOGC
|
7.1 | Ki | 25 | — | |
OWRXHGAFWZFFCW
|
7.1 | Ki | 113 | — | |
PUYIXDDMOUMMRR
|
7.1 | Ki | 27 | — | |
QFHRPRDSAHFZEG
|
7.1 | Ki | 6 | — | |
RGNHKJWHFIPHIM
|
7.1 | Ki | 66 | — | |
SJLQDZDKTVBBLP
|
7.1 | Ki | 9 | — | |
SMRWVXLSRJWVBF
|
7.1 | Ki | 25 | — | |
ZCXXFPLQFFRMPN
|
7.1 | Ki | 12 | — | |
ZRTWUBWXIGHVET
|
7.1 | Ki | 10 | — | |
LBMPEUDJKWLTOC
|
7.1 | IC50 | 6 | — | |
SDZRYLPROGBZMB
|
7.1 | IC50 | 8 | — | |
BPNNZZBLGSVSAA
|
7.0 | IC50 | 7 | — | |
USBKPWRTJAXTBS
|
7.0 | IC50 | 16 | Yes | |
IYNFVHYXEIOETE
|
7.0 | Kd | 2 | — | |
AEYLJTAIDDIOBA
|
7.0 | Ki | 53 | — | |
AOBLBPWPSKBHSI
|
7.0 | Ki | 55 | — | |
MVJMMLFMPWITEJ
|
7.0 | Ki | 110 | — | |
OPOGDZANLATWGS
|
7.0 | Ki | 9 | — | |
SYSUZXPGQXEWCZ
|
7.0 | Ki | 10 | — | |
GLXJGZLTPLOTJM
|
7.0 | IC50 | 4 | — | |
LAMWYYXJYIQOQL
|
7.0 | IC50 | 16 | Yes | |
PBCZSGKMGDDXIJ
|
7.0 | IC50 | 68 | Yes | |
MSROHJGQUMVBTJ
|
7.0 | IC50 | 3 | — | |
FHISAROGPSYNME
|
7.0 | Ki | 10 | — | |
XKFSQFMROSGGGZ
|
7.0 | IC50 | 4 | — | |
NXSJMRCTGYTSTK
|
6.9 | Kd | 200 | — | |
BJLOBSMGZUMYOP
|
6.9 | IC50 | 8 | — | |
XYIJINQWIOZSGI
|
6.9 | IC50 | 8 | Yes |