Target Details
| UniProt AC | P17612 |
|---|---|
| Gene Symbol | PRKACA |
| Protein Name | cAMP-dependent protein kinase catalytic subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 453
- Clinical molecules 52
- Avg pChEMBL 6.97
KEGG Pathways (72)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy - animal
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Neuroactive ligand signaling
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin-regulated water reabsorption
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (4)
Active Molecules (453)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OARXLGLBMAHALM
|
8.1 | IC50 | 12 | Yes | |
WDARYLSSWBWVCU
|
8.1 | Ki | 49 | — | |
JXPHKZGTRJJKLA
|
8.1 | IC50 | 3 | — | |
ZNQFWMICKJTIBV
|
8.1 | IC50 | 4 | — | |
KYQSFDSQEWSVRH
|
8.0 | Kd | 2 | — | |
AXTAPYRUEKNRBA
|
8.0 | Kd | 24 | — | |
GWJHMRBQEUHFOC
|
8.0 | Ki | 42 | — | |
PLHUMPJXRHMFFR
|
8.0 | Ki | 28 | — | |
QTMFCQXLQBJZQU
|
8.0 | IC50 | 4 | — | |
LKHWQSZVOZRQIZ
|
8.0 | IC50 | 4 | — | |
BGYVWFZMYBWCNY
|
7.9 | Ki | 30 | — | |
BSFNGHCTZDCQBF
|
7.9 | Ki | 93 | — | |
JRVSFZKYQCETAH
|
7.9 | Ki | 19 | — | |
RFVBRKXQYUDGIO
|
7.9 | Ki | 23 | — | |
UDRXOUVRNMKWQA
|
7.9 | Ki | 8 | — | |
XSRHBCYNCKAFKS
|
7.9 | Ki | 45 | — | |
ZKZXNDJNWUTGDK
|
7.9 | Ki | 14 | — | |
IPEXHQGMTHOKQV
|
7.9 | Kd | 12 | — | |
UMTWTCVTRDYHQQ
|
7.9 | IC50 | 4 | — | |
BNFMNOMUDQORMA
|
7.8 | IC50 | 4 | — | |
IIRWNGPLJQXWFJ
|
7.8 | Kd | 21 | — | |
WHPGUDAVAIYVRR
|
7.8 | IC50 | 4 | — | |
XXBKLDUYHYSMNJ
|
7.8 | IC50 | 4 | — | |
GIPRMCJMIWRNNH
|
7.8 | IC50 | 4 | — | |
KHGPYYFCIAISBU
|
7.8 | Ki | 31 | — | |
LOCWELCIOZHZHE
|
7.8 | Ki | 11 | — | |
XNWKXXIGSPPPBH
|
7.8 | Ki | 31 | — | |
GQEPXNDANQTLHI
|
7.8 | IC50 | 4 | — | |
NVSJOASGKCGXBZ
|
7.7 | IC50 | 16 | Yes | |
HKSZLNNOFSGOKW
|
7.7 | Kd | 213 | — | |
KGPGFQWBCSZGEL
|
7.7 | Kd | 59 | Yes | |
BPNUQXPIQBZCMR
|
7.7 | Ki | 60 | — | |
URNZTLZSAVLTIZ
|
7.7 | Ki | 26 | — | |
UYGYYOIUVFMGKQ
|
7.7 | Ki | 30 | — | |
VVEGARMQKNYDID
|
7.7 | Ki | 24 | — | |
XFWUTMHVDGPWLH
|
7.7 | Ki | 75 | — | |
UMDIEKHQTFPTBH
|
7.7 | IC50 | 6 | — | |
SOPDRJHPMMUFQM
|
7.6 | IC50 | 2 | — | |
UXIGAYGUDGBPOS
|
7.6 | IC50 | 6 | — | |
ZCVGUOHAEJQFRY
|
7.6 | IC50 | 6 | — | |
HNXJWWRRSGDVIW
|
7.6 | Ki | 13 | — | |
LPILBMJJRGTKOQ
|
7.6 | Ki | 27 | — | |
SLKCVFPEQGHNSI
|
7.6 | Ki | 29 | — | |
XPHWIERLJBFPFV
|
7.6 | Ki | 69 | — | |
XUFLBSMTYMFOQH
|
7.6 | Ki | 43 | — | |
YPJJSXBVVGPFHA
|
7.6 | Ki | 18 | — | |
ZKLJKKASNXVQBZ
|
7.6 | Ki | 27 | — | |
POTTVLREWUNNRO
|
7.6 | IC50 | 17 | Yes | |
LYADGAGFYYXXIO
|
7.6 | IC50 | 82 | — | |
NKWSAYGUIMPROA
|
7.5 | IC50 | 10 | — |