Target Details
| UniProt AC | P17612 |
|---|---|
| Gene Symbol | PRKACA |
| Protein Name | cAMP-dependent protein kinase catalytic subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 453
- Clinical molecules 52
- Avg pChEMBL 6.97
KEGG Pathways (72)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy - animal
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Neuroactive ligand signaling
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin-regulated water reabsorption
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (4)
Active Molecules (453)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZIIWGJMMDJWIKB
|
10.3 | IC50 | 7 | — | |
HHOVRZGUSBMKKU
|
10.0 | IC50 | 9 | — | |
LBRNKEMUALCIHZ
|
10.0 | Kd | 4 | — | |
YISMQBFJYDFMAL
|
9.2 | IC50 | 46 | — | |
HKSZLNNOFSGOKW
|
9.1 | Ki | 118 | — | |
KYCYRGUYNYCBAH
|
9.0 | IC50 | 7 | — | |
SOGKOUURZPAQPP
|
9.0 | IC50 | 6 | — | |
NWMPVMMGSHXANZ
|
8.9 | Ki | 58 | — | |
LKHWQSZVOZRQIZ
|
8.8 | IC50 | 6 | — | |
LHQWPYOYDRVMFI
|
8.7 | IC50 | 10 | Yes | |
HFBCKXXEXNDPEJ
|
8.7 | IC50 | 5 | — | |
PUQFAZBAPCKZKN
|
8.6 | IC50 | 5 | — | |
UEQYJEYXWDLUAC
|
8.6 | IC50 | 2 | — | |
WSQSTYRDZFLOBK
|
8.6 | IC50 | 3 | — | |
SNUDLLACDRMNDB
|
8.6 | IC50 | 6 | — | |
DQPYZHUAILXFJI
|
8.5 | Ki | 27 | — | |
PHWHNHYZZNJPLB
|
8.5 | Ki | 16 | — | |
OFPFIAWWDTYSBZ
|
8.5 | Ki | 15 | Yes | |
XEZNMDMVOXPEQL
|
8.5 | IC50 | 3 | — | |
JHKZENPNLYAVCT
|
8.5 | IC50 | 15 | Yes | |
UMQNZSBIZJEBSD
|
8.4 | IC50 | 6 | — | |
KPJDEGAKXAUVAC
|
8.4 | Ki | 15 | Yes | |
DWXUTKBSWVUPBE
|
8.4 | Ki | 8 | — | |
GHPFQRTVUDXWCC
|
8.4 | Ki | 35 | — | |
HOYRWTWZUFFACV
|
8.4 | Ki | 28 | — | |
ZCITXZXBLWIHHP
|
8.4 | IC50 | 6 | — | |
ZPQGOZNGTXPGAU
|
8.4 | Kd | 2 | — | |
XYUFCXJZFZPEJD
|
8.3 | IC50 | 23 | Yes | |
UYFCRWONZSAYSJ
|
8.3 | IC50 | 2 | — | |
ZENNWRXLFOADLL
|
8.3 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
8.3 | IC50 | 408 | — | |
KLSYPIQWMFSSJW
|
8.3 | IC50 | 8 | — | |
QMGUOJYZJKLOLH
|
8.3 | IC50 | 21 | Yes | |
VGNKOJURPOHWJF
|
8.3 | Ki | 21 | — | |
YBFUTVSSQNLDCI
|
8.3 | IC50 | 4 | — | |
YWTBGJGMTBHQTM
|
8.3 | Ki | 65 | — | |
VUTDBZFATUOXQL
|
8.3 | IC50 | 6 | — | |
DRRUMZPUGPNKLX
|
8.3 | IC50 | 5 | — | |
FBAPHDWTBAGCKW
|
8.3 | IC50 | 3 | — | |
MAAJGIGLUACQAJ
|
8.3 | IC50 | 3 | — | |
WTVWWCQGJWIMBF
|
8.3 | IC50 | 3 | — | |
PQVIVJUHYDLYRA
|
8.2 | IC50 | 6 | — | |
LKHWQSZVOZRQIZ
|
8.2 | IC50 | 4 | — | |
IZLPTBRLODRSPG
|
8.2 | IC50 | 3 | — | |
SRONQUHCRFZABC
|
8.2 | Ki | 28 | — | |
ZWPLUYQDKWPRGX
|
8.2 | IC50 | 4 | — | |
QSSKKSGGXPWDPC
|
8.2 | IC50 | 5 | — | |
YHOBLDNPLJTSDM
|
8.2 | IC50 | 4 | — | |
GJOXRIYWDHESDF
|
8.1 | Ki | 27 | — | |
LHNSCZROXVKHFK
|
8.1 | IC50 | 3 | — |