Target Details
| UniProt AC | P17252 |
|---|---|
| Gene Symbol | PRKCA |
| Protein Name | Protein kinase C alpha type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00168 (C2) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 679
- Clinical molecules 136
- Avg pChEMBL 7.44
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor-regulated calcium reabsorption
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin secretion
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- Natural killer cell mediated cytotoxicity
- Neuroactive ligand signaling
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Vibrio cholerae infection
- Wnt signaling pathway
- mTOR signaling pathway
Active Molecules (679)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
BMGQWWVMWDBQGC
|
7.3 | IC50 | 91 | Yes | |
MDHNNGDJYHAYKJ
|
7.3 | IC50 | 12 | Yes | |
NWEVGIIUZNAZMF
|
7.3 | IC50 | 4 | — | |
OWJIKBAZUBPKGN
|
7.3 | IC50 | 6 | — | |
OWJIKBAZUBPKGN
|
7.3 | IC50 | 7 | — | |
YDELNSXADYPQGS
|
7.3 | IC50 | 15 | Yes | |
NKWSAYGUIMPROA
|
7.3 | IC50 | 10 | — | |
BETBNWGUKZUUAX
|
7.3 | IC50 | 21 | — | |
DRXBCTFIEPSCHE
|
7.3 | Ki | 2 | — | |
GQLCVGQQDYKVCM
|
7.3 | Ki | 2 | — | |
VVHIKEQUOUROGD
|
7.3 | Ki | 3 | — | |
FOPORVBLOTVXEK
|
7.3 | Ki | 5 | — | |
GQCWIZZVARXZGR
|
7.3 | IC50 | 6 | — | |
GQLCVGQQDYKVCM
|
7.3 | Ki | 2 | — | |
LRHWSAFUUBKSML
|
7.3 | Ki | 5 | — | |
SMOYJWUKHYTHIN
|
7.3 | Ki | 2 | — | |
UIZGGLNYSWRCAR
|
7.3 | Ki | 2 | — | |
CDVWLKDMFLAJTO
|
7.2 | Ki | 2 | — | |
IDMUMGBXJGYJTD
|
7.2 | Ki | 3 | — | |
XYUYSDBKGVJSKN
|
7.2 | IC50 | 5 | — | |
FDCMEPRGSNNHNX
|
7.2 | Ki | 4 | — | |
GQCWIZZVARXZGR
|
7.2 | IC50 | 6 | — | |
PBCZSGKMGDDXIJ
|
7.2 | IC50 | 68 | Yes | |
XXIWRTOLXWAEJC
|
7.2 | IC50 | 13 | Yes | |
DETMXRBVADAKAO
|
7.2 | IC50 | 3 | — | |
PKUWFMAWUYFHHA
|
7.2 | Ki | 3 | — | |
SQVAWPTVROSMDK
|
7.2 | IC50 | 2 | — | |
TUBBFDZWFNUZLH
|
7.2 | IC50 | 12 | Yes | |
UWFSHWFUBYEFAT
|
7.2 | IC50 | 6 | — | |
WQEXBJWFPAMSGJ
|
7.2 | Ki | 8 | Yes | |
NRUVICOXXLOXCB
|
7.2 | IC50 | 13 | Yes | |
XWLIHYAUFDQCQF
|
7.2 | IC50 | 3 | — | |
HHOVRZGUSBMKKU
|
7.2 | IC50 | 9 | — | |
XYUFCXJZFZPEJD
|
7.2 | IC50 | 3 | — | |
XYUFCXJZFZPEJD
|
7.2 | IC50 | 9 | — | |
XYUFCXJZFZPEJD
|
7.2 | IC50 | 23 | Yes | |
JYQVFPCZFZOPCW
|
7.2 | IC50 | 2 | — | |
MGMNDPRNDCWSMZ
|
7.2 | IC50 | 12 | Yes | |
SWZFTDYOTKYQHS
|
7.2 | IC50 | 2 | — | |
UIZGGLNYSWRCAR
|
7.2 | Ki | 2 | — | |
WOFBHAKTZOZODW
|
7.2 | IC50 | 6 | — | |
PHOVPHVCAJYUNY
|
7.2 | IC50 | 3 | — | |
DDHFNAASWMLNPJ
|
7.1 | Ki | 3 | — | |
IYPFXBNRYNDIDC
|
7.1 | IC50 | 2 | — | |
JSXUDEUMWQFINT
|
7.1 | Ki | 3 | — | |
XRZURBBBXNHUNO
|
7.1 | IC50 | 7 | Yes | |
XYUFCXJZFZPEJD
|
7.1 | IC50 | 6 | — | |
AZRVQVNCYCMXGY
|
7.1 | Ki | 2 | — | |
CUWJDZXEDIUEEW
|
7.1 | Ki | 2 | — | |
GRENHRYHWHSBLM
|
7.1 | IC50 | 12 | Yes |