Target Details
| UniProt AC | P17252 |
|---|---|
| Gene Symbol | PRKCA |
| Protein Name | Protein kinase C alpha type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00168 (C2) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 679
- Clinical molecules 136
- Avg pChEMBL 7.44
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor-regulated calcium reabsorption
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin secretion
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- Natural killer cell mediated cytotoxicity
- Neuroactive ligand signaling
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Vibrio cholerae infection
- Wnt signaling pathway
- mTOR signaling pathway
Active Molecules (679)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QUTRNEOYUSHTBW
|
7.6 | Ki | 3 | — | |
KPCVAMMFCPIUIU
|
7.5 | IC50 | 12 | Yes | |
BGFPMEIULZPARM
|
7.5 | Ki | 3 | — | |
XELZELDAOXMYOD
|
7.5 | Ki | 3 | — | |
XHUGZQWFSKJGAZ
|
7.5 | Ki | 3 | — | |
DXZRDTKQTWORHB
|
7.5 | Ki | 3 | — | |
KQEBVHBFIFTJGM
|
7.5 | Ki | 3 | — | |
WOFBHAKTZOZODW
|
7.5 | IC50 | 6 | — | |
XXDWSQPJTJZKSJ
|
7.5 | IC50 | 12 | Yes | |
ZZSBPGIGIUFJRA
|
7.5 | IC50 | 15 | Yes | |
FELQRVDTGNDOSI
|
7.5 | IC50 | 15 | Yes | |
KDOMXVVBKAYVDL
|
7.5 | Ki | 3 | — | |
MYOUXQLHWTWXON
|
7.5 | IC50 | 16 | Yes | |
OJCFURIPWIIKNL
|
7.5 | IC50 | 2 | — | |
DSXXEELGXBCYNQ
|
7.5 | IC50 | 28 | Yes | |
YDZJEODKNRAYMA
|
7.5 | IC50 | 12 | Yes | |
ZYUGNHPOVKADFZ
|
7.5 | IC50 | 11 | — | |
BPRHUHLTGPELTP
|
7.4 | IC50 | 2 | — | |
HPBJQOWLAKYNDM
|
7.4 | IC50 | 15 | Yes | |
ZQBULZYTDGUSSK
|
7.4 | Ki | 3 | Yes | |
XELZELDAOXMYOD
|
7.4 | Ki | 3 | — | |
XNWPHEQOESWIQQ
|
7.4 | IC50 | 2 | — | |
AMSOPBXQXSAAAC
|
7.4 | IC50 | 12 | Yes | |
XUTMONHBGYHWES
|
7.4 | Ki | 5 | — | |
AXRCEOKUDYDWLF
|
7.4 | IC50 | 31 | — | |
HSZCSAUAGLABDS
|
7.4 | Ki | 5 | — | |
IPBIYLHQBHMHCN
|
7.4 | Ki | 2 | — | |
IRGJDPZJEUYSKS
|
7.4 | IC50 | 7 | — | |
IRGJDPZJEUYSKS
|
7.4 | IC50 | 9 | — | |
IRGJDPZJEUYSKS
|
7.4 | IC50 | 9 | — | |
IRGJDPZJEUYSKS
|
7.4 | IC50 | 6 | — | |
KEBMSGAJMPWLNS
|
7.4 | IC50 | 7 | Yes | |
KJGUOQMSLKZPAT
|
7.4 | IC50 | 17 | Yes | |
OWJIKBAZUBPKGN
|
7.4 | IC50 | 6 | — | |
OWJIKBAZUBPKGN
|
7.4 | IC50 | 7 | — | |
ZOGSVRRXRLSQNC
|
7.4 | IC50 | 6 | — | |
NTUVEMUMVHHACY
|
7.4 | IC50 | 12 | Yes | |
INDMCILJGPHHCG
|
7.4 | Ki | 3 | — | |
IPBIYLHQBHMHCN
|
7.4 | Ki | 2 | — | |
OSVUGUHRKMMBSE
|
7.4 | Kd | 170 | — | |
PACFXFSASUOOLC
|
7.4 | IC50 | 2 | — | |
KOZFSFOOLUUIGY
|
7.3 | IC50 | 88 | Yes | |
OHMCEYCPFVOSNY
|
7.3 | IC50 | 3 | — | |
DLMIREIQJNSNMF
|
7.3 | Ki | 3 | — | |
WKZTVBCDQYBGBO
|
7.3 | IC50 | 16 | Yes | |
VEMLCWMDXJGJLI
|
7.3 | Ki | 8 | Yes | |
XYUFCXJZFZPEJD
|
7.3 | IC50 | 9 | — | |
FDFNBRWULOMEEQ
|
7.3 | Ki | 3 | — | |
NJJRJFLBWPUKOP
|
7.3 | IC50 | 2 | — | |
SMOYJWUKHYTHIN
|
7.3 | Ki | 2 | — |