Target Details
| UniProt AC | P17252 |
|---|---|
| Gene Symbol | PRKCA |
| Protein Name | Protein kinase C alpha type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00168 (C2) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 679
- Clinical molecules 136
- Avg pChEMBL 7.44
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor-regulated calcium reabsorption
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin secretion
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- Natural killer cell mediated cytotoxicity
- Neuroactive ligand signaling
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Vibrio cholerae infection
- Wnt signaling pathway
- mTOR signaling pathway
Active Molecules (679)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SSAAQMIJVVUWDZ
|
9.0 | IC50 | 2 | — | |
UZCZCOMLMMSRLY
|
9.0 | IC50 | 6 | — | |
XSJFPSCYMJFDNI
|
9.0 | Ki | 7 | — | |
GAOWZWXUASHKMF
|
9.0 | IC50 | 2 | — | |
BQJRUJTZSGYBEZ
|
8.9 | Kd | 13 | Yes | |
KYJCVYZGCYEQEA
|
8.9 | IC50 | 2 | — | |
UJKQZOOHKSDLBL
|
8.9 | IC50 | 2 | — | |
YHFWETXESAFRRE
|
8.9 | IC50 | 2 | — | |
ZYKISFVIHSEGIE
|
8.9 | IC50 | 2 | — | |
KMFOKKGKNMQAAN
|
8.8 | IC50 | 6 | — | |
URLJNGHIJZMXTK
|
8.8 | IC50 | 6 | — | |
MWKSRKSEWLRPBL
|
8.8 | Kd | 1075 | — | |
ZOLFIIXPYNTFPH
|
8.8 | IC50 | 2 | — | |
CKQYXXGKHKORSG
|
8.8 | IC50 | 2 | — | |
NVSJOASGKCGXBZ
|
8.8 | IC50 | 16 | Yes | |
ZOLWRJUQMXEKEO
|
8.8 | IC50 | 6 | — | |
DKGIQYXYEVWNNO
|
8.7 | IC50 | 2 | — | |
TVJVIPXZACZIIC
|
8.7 | IC50 | 2 | — | |
VDBJPTBJJMQNOW
|
8.7 | IC50 | 6 | — | |
HLTRFCVVQYHUFQ
|
8.7 | IC50 | 2 | — | |
NPIKPVAKTCZWAG
|
8.7 | IC50 | 2 | — | |
XXJXHXJWQSCNPX
|
8.7 | IC50 | 7 | — | |
GDZULWKNFKCRJP
|
8.7 | IC50 | 7 | — | |
QYBVZIIWBRIXMX
|
8.7 | IC50 | 12 | Yes | |
YCLDWGHXCMAHSI
|
8.7 | IC50 | 2 | — | |
OAVGBZOFDPFGPJ
|
8.7 | IC50 | 42 | Yes | |
SKUHDUHJJACTNK
|
8.7 | IC50 | 2 | — | |
CVCIQKJLZNEUAZ
|
8.7 | IC50 | 7 | Yes | |
JZLFYMHIISZQCZ
|
8.7 | IC50 | 12 | Yes | |
FFAVQEMVMBSPQF
|
8.6 | IC50 | 2 | — | |
VEKVVEWREDUQML
|
8.6 | IC50 | 2 | — | |
AAFUKFIIJDVJOX
|
8.6 | IC50 | 2 | — | |
HOWICUYRWBCICG
|
8.6 | IC50 | 6 | — | |
LPIHDMXDUPXXEU
|
8.6 | IC50 | 6 | — | |
VWVYILCFSYNJHF
|
8.5 | IC50 | 49 | — | |
XKEOGEXDEKIDNA
|
8.5 | Ki | 2 | — | |
HKSZLNNOFSGOKW
|
8.5 | IC50 | 408 | — | |
CPXHOALOZNWMML
|
8.5 | Ki | 3 | — | |
COCXXLGXRJTCQZ
|
8.5 | IC50 | 6 | — | |
DSQFKUKVDCXORL
|
8.5 | Kd | 4 | — | |
RETKZRRHASOPND
|
8.5 | IC50 | 2 | — | |
HFPUIOYUZROFHG
|
8.4 | IC50 | 6 | — | |
JUFIOUVSLDZPAJ
|
8.4 | IC50 | 2 | — | |
UYBWOWHCXDBQRO
|
8.4 | IC50 | 6 | — | |
OQICVMYHDNIADM
|
8.4 | IC50 | 6 | — | |
PHEDXBVPIONUQT
|
8.4 | Ki | 6 | Yes | |
DSJDMJAWKIASAB
|
8.4 | IC50 | 2 | — | |
NHJKYPHIWOPLHI
|
8.4 | IC50 | 2 | — | |
XKEOGEXDEKIDNA
|
8.3 | Ki | 3 | — | |
YRYJOPMCJLSMNU
|
8.3 | IC50 | 6 | — |