Target Details
| UniProt AC | P17252 |
|---|---|
| Gene Symbol | PRKCA |
| Protein Name | Protein kinase C alpha type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00168 (C2) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 679
- Clinical molecules 136
- Avg pChEMBL 7.44
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor-regulated calcium reabsorption
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin secretion
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- Natural killer cell mediated cytotoxicity
- Neuroactive ligand signaling
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Vibrio cholerae infection
- Wnt signaling pathway
- mTOR signaling pathway
Active Molecules (679)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NJDCTLINWXDFST
|
9.5 | IC50 | 2 | — | |
MLWUDVHJKVMILP
|
9.4 | IC50 | 2 | — | |
VVRRZOFLLJAMIK
|
9.4 | IC50 | 11 | — | |
FANQQVWXAKUWNI
|
9.4 | IC50 | 6 | — | |
FEFPSHIDVWKVSO
|
9.4 | IC50 | 4 | — | |
NQESDTBKBPAEPS
|
9.4 | IC50 | 2 | — | |
PPSTZDPKWJXFIH
|
9.4 | IC50 | 2 | — | |
RHJPBGWFGOAEID
|
9.4 | Ki | 8 | Yes | |
UPSXKHFTVWTQRJ
|
9.4 | IC50 | 2 | — | |
PLIDEIVUYFAECO
|
9.4 | IC50 | 2 | — | |
FCYKUTUWVZTVAK
|
9.4 | Kd | 4 | — | |
UZDDRLFGKXVQQG
|
9.3 | IC50 | 2 | — | |
MJQUEDHRCUIRLF
|
9.3 | Ki | 4 | — | |
OZTYUUKHFRSKCQ
|
9.3 | IC50 | 2 | — | |
HODOOWOVFQSXBB
|
9.3 | IC50 | 6 | — | |
QHJQKYAQVKTFLI
|
9.3 | IC50 | 2 | — | |
SUQYTYOVPXAUGB
|
9.3 | Ki | 5 | — | |
WAKGEHXTOOFEAE
|
9.3 | IC50 | 27 | — | |
XFQSFVPULNZYER
|
9.3 | IC50 | 2 | — | |
ZMHXVAQNZDUNOG
|
9.3 | IC50 | 6 | — | |
CDSMPVVXLHABBR
|
9.3 | IC50 | 2 | — | |
QZVQSVZEEJEZSI
|
9.3 | Kd | 5 | — | |
ODKAPLPAZCAUMR
|
9.3 | IC50 | 2 | — | |
SUQYTYOVPXAUGB
|
9.3 | Ki | 3 | — | |
MZHAAXPSUZZVJO
|
9.3 | IC50 | 2 | — | |
NSDQNZWGKOYDRS
|
9.3 | IC50 | 2 | — | |
UVMAGXADFJGZHF
|
9.2 | IC50 | 2 | — | |
TUJXMCOKEYNEHL
|
9.2 | IC50 | 2 | — | |
WJNGWUFYYQTNGU
|
9.2 | IC50 | 2 | — | |
WPDAGVJJKLBFOI
|
9.2 | IC50 | 2 | — | |
REGYZNVOEPVCIC
|
9.2 | IC50 | 2 | — | |
MFDKBLCTDGSTAK
|
9.2 | IC50 | 2 | — | |
CEUSLGXUKGZQEI
|
9.1 | IC50 | 4 | — | |
FBYHLMJXXHAYDR
|
9.1 | IC50 | 2 | — | |
QFVOPUFBADFYEL
|
9.1 | IC50 | 3 | — | |
ZNFICDKPLIEJJT
|
9.1 | IC50 | 2 | — | |
CKAIRTHTMUCHRJ
|
9.1 | IC50 | 2 | — | |
MNLOLQHZWGLJBO
|
9.1 | IC50 | 2 | — | |
UZGZCPNOEILBMK
|
9.1 | IC50 | 2 | — | |
ZZMMPNUJLCNYOP
|
9.1 | IC50 | 2 | — | |
HTPZZARNXXDSIZ
|
9.1 | IC50 | 2 | — | |
IDSZLHFEKAUIOL
|
9.1 | IC50 | 7 | Yes | |
SOEHEJRHIBCBAH
|
9.1 | IC50 | 2 | — | |
XNMSYXSCPKOHED
|
9.1 | IC50 | 2 | — | |
TUIMWIXUUASFOT
|
9.0 | IC50 | 2 | — | |
XLYVQVWMTOLDNL
|
9.0 | IC50 | 21 | — | |
XLYVQVWMTOLDNL
|
9.0 | IC50 | 21 | — | |
BBBHEOUFBLBBFQ
|
9.0 | IC50 | 2 | — | |
ISVGNINBCCPWJK
|
9.0 | IC50 | 2 | — | |
JMRKHPQFNFPPIB
|
9.0 | IC50 | 3 | — |