Target Details
| UniProt AC | P17252 |
|---|---|
| Gene Symbol | PRKCA |
| Protein Name | Protein kinase C alpha type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00168 (C2) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 679
- Clinical molecules 136
- Avg pChEMBL 7.44
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor-regulated calcium reabsorption
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin secretion
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- Natural killer cell mediated cytotoxicity
- Neuroactive ligand signaling
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Vibrio cholerae infection
- Wnt signaling pathway
- mTOR signaling pathway
Active Molecules (679)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HCJOTKSJPHFVJC
|
6.7 | IC50 | 6 | — | |
NSFGGHWNWJTVMO
|
6.7 | IC50 | 5 | — | |
SDEAUNNPTULCST
|
6.7 | Ki | 3 | — | |
TWUWFRLZDWDJLT
|
6.7 | Ki | 10 | Yes | |
NTXWXFSAJRMWNA
|
6.7 | IC50 | 15 | — | |
OLYSKMGKJANIPC
|
6.7 | Ki | 2 | — | |
RAOJISQDGOOXTK
|
6.7 | IC50 | 14 | Yes | |
ZWFTUJOJJZSCMP
|
6.7 | Ki | 2 | — | |
PQWWKDOKHDWZBH
|
6.7 | IC50 | 6 | — | |
PQWWKDOKHDWZBH
|
6.7 | IC50 | 6 | — | |
YRTMRGPNXUUDTD
|
6.7 | IC50 | 5 | — | |
MEXUTNIFSHFQRG
|
6.7 | IC50 | 21 | Yes | |
WYMCAIGTNRBMBV
|
6.7 | IC50 | 2 | — | |
GZJKVFKNTQXSQM
|
6.7 | IC50 | 12 | Yes | |
NIUBYBAPAVVDMG
|
6.7 | IC50 | 6 | — | |
NIUBYBAPAVVDMG
|
6.7 | IC50 | 6 | — | |
QRBQWXYKYOJHCY
|
6.7 | IC50 | 3 | — | |
UIARLYUEJFELEN
|
6.7 | Kd | 289 | Yes | |
USEYXZSHZLLAJS
|
6.7 | IC50 | 6 | — | |
WPSBCJTXGDVGAZ
|
6.7 | IC50 | 5 | — | |
MZNUNTIEUOYNNT
|
6.6 | IC50 | 12 | Yes | |
OXEOHAXVZADDOC
|
6.6 | IC50 | 12 | Yes | |
PWTCCMJTPHCGMS
|
6.6 | Ki | 3 | — | |
SZUVPYWZPMECBT
|
6.6 | IC50 | 2 | — | |
ZWZYAJQDNYIAOM
|
6.6 | IC50 | 2 | — | |
VNPLXDZLURAZHZ
|
6.6 | IC50 | 5 | — | |
YSVVBGPTTSJYPA
|
6.6 | IC50 | 12 | Yes | |
IVGCXWIFBNPPBW
|
6.6 | IC50 | 6 | — | |
ZEYTZKVCOZMUKL
|
6.6 | IC50 | 5 | — | |
IIMMUGRHSXMDBU
|
6.6 | IC50 | 4 | — | |
KOZFSFOOLUUIGY
|
6.6 | IC50 | 26 | — | |
NPSIUNUHCPZEFG
|
6.6 | Ki | 3 | — | |
NTRDTMDMDUVYSM
|
6.6 | IC50 | 3 | — | |
QUTRBEMNJLJANB
|
6.6 | IC50 | 4 | — | |
SSZFVGXDYBMVDD
|
6.6 | IC50 | 12 | Yes | |
VREDQQFDKBEALJ
|
6.6 | IC50 | 5 | — | |
VWBSMGFTNCQOMB
|
6.6 | IC50 | 3 | — | |
JOOTZGPUMCZHLH
|
6.6 | IC50 | 5 | — | |
MKPSMRQVGPTYRL
|
6.6 | IC50 | 5 | — | |
OBNHABKOCPUFDD
|
6.6 | Ki | 3 | — | |
PBCZSGKMGDDXIJ
|
6.6 | IC50 | 12 | Yes | |
SHNAOUAXXNYCRS
|
6.6 | IC50 | 2 | — | |
KOVNFJBXMBASSU
|
6.6 | IC50 | 4 | — | |
LAOIBIIMKUINJL
|
6.6 | IC50 | 12 | Yes | |
MKPSMRQVGPTYRL
|
6.6 | IC50 | 6 | — | |
RVIJQMOQZFCSHL
|
6.6 | Ki | 8 | Yes | |
VZTQRSJQRWBYFW
|
6.6 | IC50 | 2 | — | |
ZFJJSMUJXGVEEW
|
6.6 | IC50 | 2 | — | |
HTLCUINLPKLTDS
|
6.6 | IC50 | 2 | — | |
IXOVKVHWGKDXKQ
|
6.6 | IC50 | 12 | Yes |