Target Details
| UniProt AC | P17252 |
|---|---|
| Gene Symbol | PRKCA |
| Protein Name | Protein kinase C alpha type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00168 (C2) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 679
- Clinical molecules 136
- Avg pChEMBL 7.44
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor-regulated calcium reabsorption
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin secretion
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- Natural killer cell mediated cytotoxicity
- Neuroactive ligand signaling
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Vibrio cholerae infection
- Wnt signaling pathway
- mTOR signaling pathway
Active Molecules (679)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WTXAWDOYPWWUJL
|
10.1 | IC50 | 11 | — | |
AODINEOJAWVRMB
|
9.9 | IC50 | 2 | — | |
AXXPOMJMORIBKL
|
9.9 | IC50 | 2 | — | |
CCFSCBCNTYCQQD
|
9.9 | IC50 | 4 | — | |
DFHNPLPBHYMUAW
|
9.9 | IC50 | 2 | — | |
DWUYMGRQDSNZNZ
|
9.9 | IC50 | 2 | — | |
KNTODVAJZPLTBO
|
9.9 | IC50 | 4 | — | |
KQKVTOFNZCMSEP
|
9.9 | IC50 | 2 | — | |
LBKFIWNOGYSLHE
|
9.9 | IC50 | 2 | — | |
LJCBQNDNKZTPPD
|
9.9 | IC50 | 2 | — | |
LLMXWBSEQIDLJG
|
9.9 | IC50 | 5 | — | |
OLYCNNWWUIENNA
|
9.9 | IC50 | 2 | — | |
OWWZQKFMHXISPG
|
9.9 | IC50 | 2 | — | |
PBMUEOYWGJZICW
|
9.9 | IC50 | 4 | — | |
SSXCVTWCXHGTLK
|
9.9 | IC50 | 11 | — | |
VHLRDCSSMVVRQX
|
9.9 | IC50 | 2 | — | |
VHOMUDQDZZWLSZ
|
9.9 | IC50 | 3 | — | |
VJMOXJYFZUYUTA
|
9.9 | IC50 | 2 | — | |
WESMIFKYYUDSHE
|
9.9 | IC50 | 2 | — | |
YNARAQPWBNWRIS
|
9.9 | IC50 | 3 | — | |
JAMGGIDPOXFRAM
|
9.8 | Ki | 3 | — | |
KTGVSZYYHHRRGW
|
9.8 | IC50 | 11 | — | |
ZVWUCVHEPQALQU
|
9.8 | IC50 | 2 | — | |
JWHUZKCDLIXMSE
|
9.8 | IC50 | 4 | — | |
VIESIZQAHOPEBR
|
9.8 | IC50 | 11 | — | |
IUQRWIKPYXRDAP
|
9.8 | IC50 | 2 | — | |
YIAUOBNZXMZCFP
|
9.8 | IC50 | 2 | — | |
NVYBXIDWOJVGQI
|
9.8 | IC50 | 11 | — | |
WNEWTOQENXHIHL
|
9.8 | IC50 | 2 | — | |
APVOCXHEVZBCGS
|
9.7 | IC50 | 11 | — | |
FVAXCXHKGMJCLC
|
9.7 | IC50 | 4 | — | |
WFUUKKJTZMFANX
|
9.7 | IC50 | 2 | — | |
FEFAAFLIBQXOAO
|
9.7 | IC50 | 2 | — | |
LPLRIFJSFFHUQM
|
9.7 | IC50 | 3 | — | |
AAKDVUMRVXYBST
|
9.7 | IC50 | 2 | — | |
DHTLXMRCLSUJPP
|
9.7 | IC50 | 11 | — | |
NGBKJSCBALSPIB
|
9.6 | IC50 | 2 | — | |
CDJHHHAMGANBEP
|
9.6 | IC50 | 2 | — | |
ISHUULBGXOVLLF
|
9.6 | IC50 | 2 | — | |
SUKUYCBPKLCSMU
|
9.6 | IC50 | 2 | — | |
REAZZDPREXHWNV
|
9.6 | Ki | 7 | — | |
YCLDWGHXCMAHSI
|
9.6 | IC50 | 2 | — | |
DFRRTVUTEGCPAR
|
9.6 | IC50 | 2 | — | |
BQJRUJTZSGYBEZ
|
9.6 | Kd | 4 | — | |
LTFWFNLDCHAVQF
|
9.5 | IC50 | 2 | — | |
BPPBYLMSKBUXJS
|
9.5 | IC50 | 2 | — | |
SUKUYCBPKLCSMU
|
9.5 | IC50 | 2 | — | |
HTPZZARNXXDSIZ
|
9.5 | IC50 | 2 | — | |
CFGWNLDQFLAEHP
|
9.5 | IC50 | 2 | — | |
DGKQFAFCFMHDSZ
|
9.5 | IC50 | 2 | — |