Target Details
| UniProt AC | P16615 |
|---|---|
| Gene Symbol | ATP2A2 |
| Protein Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF13246 (Cation_ATPase) PF00689 (Cation_ATPase_C) PF00690 (Cation_ATPase_N) PF00122 (E1-E2_ATPase) PF08282 (Hydrolase_3) |
Summary
- Multi-target molecules 5
- Clinical molecules 0
- Avg pChEMBL 7.38
KEGG Pathways (16)
- Adrenergic signaling in cardiomyocytes
- Alzheimer disease
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Cardiac muscle contraction
- Diabetic cardiomyopathy
- Dilated cardiomyopathy
- Efferocytosis
- Hypertrophic cardiomyopathy
- Osteoclast differentiation
- Pancreatic secretion
- Pathways of neurodegeneration - multiple diseases
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (2)
Active Molecules (5)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QLNOFWPLTFNJPW
|
8.0 | Ki | 2 | — | |
MWKSRKSEWLRPBL
|
7.6 | Kd | 1075 | — | |
DVYYXLNVAXSASA
|
7.6 | Ki | 2 | — | |
CNZIQHGDUXRUJS
|
7.0 | IC50 | 2 | — | |
IXFPJGBNCFXKPI
|
6.7 | IC50 | 2 | — |