Target Details
| UniProt AC | P16234 |
|---|---|
| Gene Symbol | PDGFRA |
| Protein Name | Platelet-derived growth factor receptor alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07679 (I-set) PF25305 (Ig_PDGFR_d4) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 860
- Clinical molecules 94
- Avg pChEMBL 7.24
KEGG Pathways (22)
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Choline metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- Focal adhesion
- Gap junction
- Glioma
- Human cytomegalovirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
Associated Diseases (4)
Active Molecules (860)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NEQZWEXWOFPKOT
|
9.6 | IC50 | 9 | Yes | |
SHPFDGWALWEPGS
|
9.3 | Kd | 35 | — | |
RITAVMQDGBJQJZ
|
9.3 | Kd | 43 | — | |
HKSZLNNOFSGOKW
|
9.2 | IC50 | 408 | — | |
ZKFZKBXDZAXEBR
|
9.1 | IC50 | 2 | — | |
WPHKIQPVPYJNAX
|
9.1 | Ki | 81 | — | |
ORRNXRYWGDUDOG
|
9.1 | IC50 | 5 | — | |
VMAAFUOXTWPYRN
|
9.0 | IC50 | 9 | Yes | |
BGVQPQHIUOTLBT
|
9.0 | Kd | 6 | — | |
FLJOFQUXYAWOPE
|
9.0 | IC50 | 2 | — | |
GEATXDJAPAHPTP
|
9.0 | IC50 | 10 | — | |
CTNPALGJUAXMMC
|
9.0 | Kd | 151 | — | |
IALDYVNFZAPNJV
|
9.0 | IC50 | 11 | — | |
PHXJVRSECIGDHY
|
9.0 | IC50 | 59 | — | |
XLYVQVWMTOLDNL
|
8.9 | IC50 | 21 | — | |
XLYVQVWMTOLDNL
|
8.9 | IC50 | 21 | — | |
KUNZDWIFPOMUOX
|
8.9 | Ki | 36 | — | |
NGKALCMOLVCFHL
|
8.9 | Kd | 5 | — | |
SUXYGJZMCWKJJI
|
8.9 | IC50 | 26 | Yes | |
BRTHUECZMVKNMQ
|
8.8 | Ki | 31 | — | |
DWYRIWUZIJHQKQ
|
8.8 | IC50 | 3 | — | |
FZUIMQXCCXUHPW
|
8.8 | IC50 | 2 | — | |
DZSUJUOJJJCWGG
|
8.7 | IC50 | 55 | Yes | |
AIKGYQDFIJRQIY
|
8.7 | IC50 | 9 | — | |
DMQYDVBIPXAAJA
|
8.7 | IC50 | 4 | — | |
IFPPYSWJNWHOLQ
|
8.7 | Ki | 52 | Yes | |
MJJXPCMDOLZDMW
|
8.7 | IC50 | 2 | — | |
PCSKFQHKWWNIKM
|
8.7 | IC50 | 7 | — | |
TZKBVRDEOITLRB
|
8.7 | IC50 | 7 | — | |
IKQQCPGYCMFUKJ
|
8.7 | IC50 | 2 | — | |
ZBNZXTGUTAYRHI
|
8.7 | Kd | 102 | Yes | |
WINHZLLDWRZWRT
|
8.6 | IC50 | 201 | Yes | |
QXPNJMHRUZCEAP
|
8.6 | IC50 | 14 | — | |
UXXQOJXBIDBUAC
|
8.6 | Kd | 21 | Yes | |
ADLPKFFMGIJZIM
|
8.6 | Ki | 44 | — | |
NKEUPUJTVALZIK
|
8.6 | Ki | 28 | — | |
VCFDMLBPASGZTP
|
8.6 | Ki | 38 | — | |
SPMVMDHWKHCIDT
|
8.6 | IC50 | 30 | — | |
JEUQHZZAJFLFGO
|
8.5 | IC50 | 4 | — | |
OIANGKGOYKDGQV
|
8.5 | Kd | 10 | — | |
QSWVENZGENITTQ
|
8.5 | IC50 | 4 | — | |
XHCPCYVQXFHJAU
|
8.5 | IC50 | 12 | — | |
YYPVGQBXTJNGFW
|
8.5 | IC50 | 4 | — | |
GJKVMXDBPDDFHI
|
8.5 | Ki | 27 | — | |
JVCWPUFNLFSKFS
|
8.5 | IC50 | 5 | — | |
VKBFHTIUXUCYRQ
|
8.5 | Ki | 66 | — | |
AZOXWOCICFEBCQ
|
8.5 | IC50 | 11 | — | |
SPMVMDHWKHCIDT
|
8.5 | IC50 | 5 | — | |
CJPNTWIJDMEPOG
|
8.5 | IC50 | 2 | — | |
WEDWUMJCHQDOEH
|
8.5 | IC50 | 3 | — |