Target Details
| UniProt AC | P15056 |
|---|---|
| Gene Symbol | BRAF |
| Protein Name | Serine/threonine-protein kinase B-raf |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF07714 (PK_Tyr_Ser-Thr) PF02196 (RBD) |
Summary
- Multi-target molecules 2,643
- Clinical molecules 78
- Avg pChEMBL 7.81
KEGG Pathways (44)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Bladder cancer
- Breast cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanoma
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Progesterone-mediated oocyte maturation
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Serotonergic synapse
- Thyroid cancer
- Vascular smooth muscle contraction
- cAMP signaling pathway
- mTOR signaling pathway
Associated Diseases (10)
Active Molecules (2,643)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FCNIJEGJNGSXDC
|
8.9 | IC50 | 2 | — | |
FLNNBUNPCWDUJJ
|
8.9 | IC50 | 2 | — | |
KDNOQIGPPRAKPY
|
8.9 | IC50 | 2 | — | |
KRNVXEUEAHAQCR
|
8.9 | IC50 | 2 | — | |
KTIDFNQTLHQGAM
|
8.9 | IC50 | 2 | — | |
MILPDEPRDAKOOR
|
8.9 | IC50 | 2 | — | |
OFHHKPCWLMSMEO
|
8.9 | IC50 | 2 | — | |
OKTYEAXGHPNKJI
|
8.9 | IC50 | 2 | — | |
PBQWRGLSSGUZOA
|
8.9 | IC50 | 2 | — | |
PLAKXVXPMSXNCB
|
8.9 | IC50 | 2 | — | |
PYHYMBDJYKFULS
|
8.9 | IC50 | 2 | — | |
PYONYXZCUHOXDY
|
8.9 | IC50 | 2 | — | |
REGQODFLIASNHU
|
8.9 | IC50 | 2 | — | |
RJYWRJSAZYVNNO
|
8.9 | IC50 | 2 | — | |
RMESOPJVHOLUCH
|
8.9 | IC50 | 2 | — | |
RWSDHIITPFFSRT
|
8.9 | IC50 | 2 | — | |
SNYHPSCINXLEIQ
|
8.9 | IC50 | 2 | — | |
UOLXDFIAGUDKAE
|
8.9 | IC50 | 2 | — | |
UWPBXWOCFRZZEJ
|
8.9 | IC50 | 2 | — | |
WYOQZZQRRFKXAE
|
8.9 | IC50 | 2 | — | |
XTWLCVDEMHJLNH
|
8.9 | IC50 | 2 | — | |
XWQFRYNHIVMONA
|
8.9 | IC50 | 2 | — | |
YOOGGUOGZRQVCH
|
8.9 | IC50 | 2 | — | |
NHIDIWOUTDGPHN
|
8.9 | IC50 | 2 | — | |
OIVLQHCLBDDPPE
|
8.9 | IC50 | 2 | — | |
OULIDKUUWCWYAF
|
8.9 | IC50 | 2 | — | |
PRPZEFLLWATTOC
|
8.9 | IC50 | 2 | — | |
UDCQMXLNHJMTMV
|
8.9 | IC50 | 2 | — | |
DDSNJNSZZOOAAH
|
8.9 | IC50 | 2 | — | |
MFAFOSJZKZAZSS
|
8.9 | IC50 | 2 | — | |
PNGGYMKHJMOIPI
|
8.9 | IC50 | 2 | — | |
UAQQBERPAFEDMA
|
8.9 | IC50 | 2 | — | |
UTVABCSMEKUFLJ
|
8.9 | pIC50 | 7 | Yes | |
YXARVHZXTQVAOP
|
8.9 | IC50 | 11 | — | |
AHLQDZCJPCLDJM
|
8.8 | IC50 | 2 | — | |
BTYBKVCFADKILK
|
8.8 | IC50 | 2 | — | |
CNBQFGVLNIZYEV
|
8.8 | IC50 | 2 | — | |
CQHCHMVSWDLQFP
|
8.8 | IC50 | 2 | — | |
DEFBACDLTQLHSG
|
8.8 | IC50 | 2 | — | |
FTOQSSWEKQRPCE
|
8.8 | IC50 | 2 | — | |
KZMIPKOLXPTHAF
|
8.8 | IC50 | 2 | — | |
NALUYXQOXMHJMM
|
8.8 | Ki | 2 | — | |
NALUYXQOXMHJMM
|
8.8 | Ki | 2 | — | |
PEVAEYPAACQFLC
|
8.8 | IC50 | 2 | — | |
QHZJPRSLBCVVRJ
|
8.8 | IC50 | 2 | — | |
RCGQFZWEIVJACO
|
8.8 | IC50 | 2 | — | |
SPUNUQAIABKRGH
|
8.8 | IC50 | 2 | — | |
UDHXRVPPXWJDAN
|
8.8 | IC50 | 2 | — | |
UKYPTBNZTNSWQG
|
8.8 | IC50 | 2 | — | |
WDFPENAKPUARAY
|
8.8 | IC50 | 2 | — |