Target Details
| UniProt AC | P15056 |
|---|---|
| Gene Symbol | BRAF |
| Protein Name | Serine/threonine-protein kinase B-raf |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF07714 (PK_Tyr_Ser-Thr) PF02196 (RBD) |
Summary
- Multi-target molecules 2,643
- Clinical molecules 78
- Avg pChEMBL 7.81
KEGG Pathways (44)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Bladder cancer
- Breast cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanoma
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Progesterone-mediated oocyte maturation
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Serotonergic synapse
- Thyroid cancer
- Vascular smooth muscle contraction
- cAMP signaling pathway
- mTOR signaling pathway
Associated Diseases (10)
Active Molecules (2,643)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WNAUAJUEJOIWKE
|
9.4 | IC50 | 2 | — | |
GIFXXPXSCMJGGJ
|
9.3 | IC50 | 2 | — | |
HTUPONJUVMCVCW
|
9.3 | IC50 | 6 | Yes | |
MLDQJTXFUGDVEO
|
9.3 | pIC50 | 85 | Yes | |
ZAYWARVMFZWGAP
|
9.3 | IC50 | 2 | — | |
WDTOWYPUXJXLOE
|
9.3 | IC50 | 3 | — | |
ZJLHDNUYXKAUGC
|
9.3 | IC50 | 2 | — | |
FYNMINFUAIDIFL
|
9.3 | IC50 | 2 | — | |
RMTGMEXYMKRUSY
|
9.3 | IC50 | 3 | — | |
BYMCFCWJXIQKBB
|
9.3 | IC50 | 2 | — | |
FXXKRWMIVAYMPU
|
9.3 | IC50 | 2 | — | |
IMXJHHQPHUBYBA
|
9.3 | IC50 | 2 | — | |
IQQLLSYZIGEGPW
|
9.3 | IC50 | 2 | — | |
JDAWBAOYRPWDSU
|
9.3 | IC50 | 2 | — | |
NRNGEHBPDHSOOR
|
9.3 | IC50 | 2 | — | |
NZQDZMBWHLVRCS
|
9.3 | IC50 | 2 | — | |
PZUHKQRSUMVMFJ
|
9.3 | IC50 | 2 | — | |
RXIUWLLWTXRNAY
|
9.3 | IC50 | 2 | — | |
TYKMBBSNBRBFQR
|
9.3 | IC50 | 2 | — | |
VWZRDTLPMXJTFJ
|
9.3 | IC50 | 2 | — | |
XCLJGHDOBNHEIT
|
9.3 | IC50 | 2 | — | |
KSBSUKHFYJLKDB
|
9.3 | IC50 | 2 | — | |
OEQUIGXPHVTTNQ
|
9.3 | IC50 | 2 | — | |
VYRFWMBEJHAIQQ
|
9.3 | IC50 | 2 | — | |
HPYJCCVZSKEWOQ
|
9.2 | IC50 | 3 | — | |
NKZJAMWPVQZVFM
|
9.2 | IC50 | 3 | — | |
QXYGLZYBRPGUEW
|
9.2 | IC50 | 2 | — | |
XVOJUYXRFDBUCC
|
9.2 | IC50 | 2 | — | |
RXSOMFNCTBYYMX
|
9.2 | IC50 | 2 | — | |
BKOSMJWAOFWFIQ
|
9.2 | IC50 | 2 | — | |
CTGTWMKGYMJBNV
|
9.2 | IC50 | 2 | — | |
DRUVICTYCPYHJJ
|
9.2 | IC50 | 2 | — | |
FJFPSNLPQKQCBP
|
9.2 | IC50 | 2 | — | |
GCLAVHRBISLBFV
|
9.2 | IC50 | 2 | — | |
GNNHCLHJDZIHMO
|
9.2 | IC50 | 2 | — | |
HWTGCLPVSGXZOV
|
9.2 | IC50 | 2 | — | |
IJFWZMGJVQXAHT
|
9.2 | IC50 | 2 | — | |
KAIOZIXFNCXYEB
|
9.2 | IC50 | 2 | — | |
LMWNSZRGFQPTAG
|
9.2 | IC50 | 2 | — | |
MCJQPONANDYORV
|
9.2 | IC50 | 2 | — | |
NCCKYASQPHYXES
|
9.2 | IC50 | 2 | — | |
NHRDFGIYVIKRAG
|
9.2 | IC50 | 2 | — | |
OGIKZKDRUHMPSK
|
9.2 | IC50 | 2 | — | |
OGXWUFWZKYNULL
|
9.2 | IC50 | 2 | — | |
OLTGUYDIYLEZAH
|
9.2 | IC50 | 2 | — | |
ONAMZFMHCGHNSP
|
9.2 | IC50 | 2 | — | |
OSIBRMJXILYOBA
|
9.2 | IC50 | 2 | — | |
QQSUYFCYUQZJDH
|
9.2 | IC50 | 2 | — | |
RMBAGGGRKNUXIE
|
9.2 | IC50 | 2 | — | |
TVZOOFYXXUNQKB
|
9.2 | IC50 | 2 | — |