Target Details
| UniProt AC | P15056 |
|---|---|
| Gene Symbol | BRAF |
| Protein Name | Serine/threonine-protein kinase B-raf |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF07714 (PK_Tyr_Ser-Thr) PF02196 (RBD) |
Summary
- Multi-target molecules 2,643
- Clinical molecules 78
- Avg pChEMBL 7.81
KEGG Pathways (44)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Bladder cancer
- Breast cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanoma
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Progesterone-mediated oocyte maturation
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Serotonergic synapse
- Thyroid cancer
- Vascular smooth muscle contraction
- cAMP signaling pathway
- mTOR signaling pathway
Associated Diseases (10)
Active Molecules (2,643)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QULKREMAADOCHU
|
10.7 | IC50 | 3 | — | |
SXWKBCDVVZZEHR
|
10.7 | IC50 | 2 | — | |
KWEFZSZCLBHIEQ
|
10.5 | IC50 | 3 | — | |
JIGTUWSTWHIQQU
|
10.4 | IC50 | 3 | — | |
CGDZXQIYUJFMAG
|
10.3 | IC50 | 3 | — | |
KGUYRZDURTZEOU
|
10.2 | IC50 | 2 | — | |
JIGTUWSTWHIQQU
|
10.1 | IC50 | 3 | — | |
NPJFYBJXZUVECB
|
10.0 | Ki | 2 | — | |
SVKJDPJZMVMETE
|
9.9 | Ki | 2 | — | |
HNYYFWGWLSEHQF
|
9.8 | IC50 | 3 | — | |
JCJSAFZMXVQVBR
|
9.8 | IC50 | 11 | Yes | |
DEZZLWQELQORIU
|
9.8 | IC50 | 7 | — | |
RIGIGAFKKVBACY
|
9.8 | Kd | 5 | — | |
SXCTZLXYGLXXRY
|
9.7 | Ki | 2 | — | |
ARBMICZOSUERLW
|
9.7 | IC50 | 2 | — | |
BXJJMVWIWRXBJU
|
9.7 | IC50 | 2 | — | |
FKUBKOPNAZUGDL
|
9.7 | IC50 | 2 | — | |
JPELQPFYUQYAPX
|
9.7 | IC50 | 2 | — | |
MRTHXFZEQBERDI
|
9.7 | IC50 | 11 | — | |
NTWKXFKERDWCRW
|
9.7 | IC50 | 2 | — | |
QBAKJEJGYGSTPA
|
9.7 | IC50 | 2 | — | |
RZCDDUDKDKUXLC
|
9.7 | IC50 | 3 | — | |
ZLWRKMXLUCZVAR
|
9.7 | Ki | 2 | — | |
NMCMBEJKNQYJAZ
|
9.6 | IC50 | 3 | — | |
BOXSRLFIMBYIRN
|
9.6 | Ki | 2 | — | |
CSVXUAKTJJDCMS
|
9.5 | IC50 | 6 | — | |
RZBDOVUMWNDQMO
|
9.5 | IC50 | 2 | — | |
YZPTWQLHPJJVQJ
|
9.5 | IC50 | 2 | — | |
ZOOUXHZNCBQCRB
|
9.5 | IC50 | 2 | — | |
JCXMPJHQZVZPHB
|
9.5 | IC50 | 2 | — | |
STYRMQOOVKCOCM
|
9.5 | IC50 | 3 | — | |
ZHNCJARBTUXWNB
|
9.5 | IC50 | 2 | — | |
HRKVZMGUPVYSKL
|
9.5 | IC50 | 3 | — | |
WBOYUDKCKRWVNR
|
9.4 | IC50 | 4 | — | |
MZPDPRITYJNRSG
|
9.4 | IC50 | 8 | Yes | |
RLWUNRNXGQENCE
|
9.4 | IC50 | 2 | — | |
JENDIFUUBSMNTQ
|
9.4 | IC50 | 2 | — | |
XBYGGIAFXHDSJP
|
9.4 | IC50 | 3 | — | |
AEJACXAFHXBVHF
|
9.4 | IC50 | 2 | — | |
DPNUITNEMBFUTB
|
9.4 | IC50 | 2 | — | |
DPTXNTRRZXCRJM
|
9.4 | IC50 | 2 | — | |
IEZYWAQNPCYLAP
|
9.4 | IC50 | 2 | — | |
OQBWUQJBAXXYLL
|
9.4 | IC50 | 2 | — | |
QUBAZPBETZNQAE
|
9.4 | IC50 | 2 | — | |
SBMKKXAOEFNNIN
|
9.4 | IC50 | 2 | — | |
VUCDTBXJRRGGMN
|
9.4 | IC50 | 2 | — | |
WZBZWEHLHGROSE
|
9.4 | IC50 | 2 | — | |
XNXYVBUDPKCWTN
|
9.4 | IC50 | 2 | — | |
XTEJDZLDLUSKQZ
|
9.4 | IC50 | 2 | — | |
YLSYFNYUEVXQIB
|
9.4 | IC50 | 2 | — |