Target Details
| UniProt AC | P14210 |
|---|---|
| Gene Symbol | HGF |
| Protein Name | Hepatocyte growth factor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00051 (Kringle) PF00024 (PAN_1) PF00089 (Trypsin) |
Summary
- Multi-target molecules 4
- Clinical molecules 1
- Avg pChEMBL 6.89
KEGG Pathways (17)
- Calcium signaling pathway
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
Associated Diseases (2)
Active Molecules (4)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
UVNDVSUMHWZESZ
|
7.2 | IC50 | 8 | Yes | |
ONSZEUCTVQJHOZ
|
7.1 | IC50 | 9 | — | |
MYPQPZOTEGVVQY
|
6.8 | IC50 | 3 | — | |
IKPJWGNTDNCFPS
|
6.5 | IC50 | 3 | — |