Target Details
| UniProt AC | P13637 |
|---|---|
| Gene Symbol | ATP1A3 |
| Protein Name | Sodium/potassium-transporting ATPase subunit alpha-3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF13246 (Cation_ATPase) PF00689 (Cation_ATPase_C) PF00690 (Cation_ATPase_N) PF00122 (E1-E2_ATPase) |
Summary
- Multi-target molecules 100
- Clinical molecules 0
- Avg pChEMBL 6.74
KEGG Pathways (19)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Bile secretion
- Carbohydrate digestion and absorption
- Cardiac muscle contraction
- Cytoskeleton in muscle cells
- Endocrine and other factor-regulated calcium reabsorption
- Gastric acid secretion
- Insulin secretion
- Mineral absorption
- Pancreatic secretion
- Protein digestion and absorption
- Proximal tubule bicarbonate reclamation
- Salivary secretion
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (4)
Active Molecules (100)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WVEGAINMKWGMQF
|
6.6 | IC50 | 8 | — | |
SBNDJGPFJSWZQO
|
6.6 | IC50 | 8 | — | |
KGKCYVKDIMEFFP
|
6.6 | IC50 | 8 | — | |
LTMHDMANZUZIPE
|
6.6 | IC50 | 10 | — | |
FNMNIFYGWCVBNZ
|
6.5 | IC50 | 8 | — | |
QFWMWJKYDUARDJ
|
6.5 | Ki | 8 | — | |
SJBJFBWDCMUDLX
|
6.5 | IC50 | 8 | — | |
BJTJHPNQMGQVLK
|
6.4 | IC50 | 8 | — | |
PDHCFMSBVAKZJF
|
6.4 | IC50 | 8 | — | |
AOJWIMOZVSIYID
|
6.4 | IC50 | 8 | — | |
CKPNOQUCOCLXEJ
|
6.4 | IC50 | 8 | — | |
FHRFLDXBGQKLCM
|
6.4 | IC50 | 8 | — | |
RHMPRGRMPQFVCB
|
6.4 | IC50 | 8 | — | |
KPIHBTYGWSGVMC
|
6.4 | IC50 | 8 | — | |
OBLROXFEDYVPLD
|
6.4 | IC50 | 8 | — | |
YTVVIRMXLLFOAP
|
6.3 | IC50 | 8 | — | |
BYXAGCCQDSIWHH
|
6.3 | IC50 | 8 | — | |
GLGPOUSKXSNBBO
|
6.3 | IC50 | 8 | — | |
WUBIBGYWUZUNNR
|
6.3 | IC50 | 8 | — | |
BPOCXSHOKZMVTQ
|
6.3 | IC50 | 8 | — | |
YFXRIQXHJOWDIA
|
6.2 | IC50 | 8 | — | |
XCZZVTGAOFXVRN
|
6.2 | IC50 | 8 | — | |
WVEGAINMKWGMQF
|
6.2 | IC50 | 8 | — | |
BYZKQAJRHRSLFB
|
6.2 | IC50 | 8 | — | |
PWSSKBVUJWPAKP
|
6.2 | IC50 | 8 | — | |
WUEJJDAJHZAUTN
|
6.2 | IC50 | 8 | — | |
CKATWOIVYBOFBX
|
6.2 | IC50 | 8 | — | |
NOMWIENSVSSXLM
|
6.1 | IC50 | 8 | — | |
OCHFCLLFHZJODH
|
6.1 | IC50 | 8 | — | |
RYPLJABMUJCZDP
|
6.1 | IC50 | 8 | — | |
AHMFXCKPRYTDAX
|
6.1 | IC50 | 8 | — | |
DUBHNQVGESAENE
|
6.1 | IC50 | 8 | — | |
SKXWHUZZZUAUTR
|
6.1 | IC50 | 8 | — | |
UPGRUNNGGMKRNL
|
6.1 | IC50 | 8 | — | |
YNSPHTBZQCLQTP
|
6.1 | IC50 | 8 | — | |
ZONVAXBTJUJNEV
|
6.1 | IC50 | 8 | — | |
YCTOKVWDUCMPQH
|
6.1 | IC50 | 8 | — | |
DVNONHRZPHVBRC
|
6.1 | IC50 | 8 | — | |
MNEBYGGATWLYSQ
|
6.0 | IC50 | 8 | — | |
SCSFIKPKBXJODT
|
6.0 | IC50 | 8 | — | |
UUJNDNMWRJVROK
|
6.0 | IC50 | 8 | — | |
BXTBYVDGHWICHN
|
6.0 | IC50 | 8 | — | |
CRFODPKTNNHLHW
|
6.0 | IC50 | 8 | — | |
FANGVRWQNKXROL
|
6.0 | IC50 | 8 | — | |
FFUHYVXTLIVSQO
|
6.0 | IC50 | 8 | — | |
KTLHLIXDVWEQDP
|
6.0 | IC50 | 8 | — | |
OMIMFIZVMAZVGL
|
6.0 | IC50 | 8 | — | |
WUBIBGYWUZUNNR
|
6.0 | IC50 | 8 | — | |
XJJAPQDCCAHZKH
|
6.0 | IC50 | 8 | — | |
ZAVBVROOKBXWAZ
|
6.0 | IC50 | 8 | — |