Target Details
| UniProt AC | P13612 |
|---|---|
| Gene Symbol | ITGA4 |
| Protein Name | Integrin alpha-4 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01839 (FG-GAP) PF08441 (Integrin_A_Ig_1) PF20805 (Integrin_A_Ig_2) PF20806 (Integrin_A_Ig_3) |
Summary
- Multi-target molecules 1,260
- Clinical molecules 0
- Avg pChEMBL 7.82
KEGG Pathways (17)
- Arrhythmogenic right ventricular cardiomyopathy
- Cell adhesion molecule (CAM) interaction
- Cytoskeleton in muscle cells
- Dilated cardiomyopathy
- ECM-receptor interaction
- Focal adhesion
- Hematopoietic cell lineage
- Human papillomavirus infection
- Hypertrophic cardiomyopathy
- IgSF CAM signaling
- Integrin signaling
- Intestinal immune network for IgA production
- Leishmaniasis
- Leukocyte transendothelial migration
- PI3K-Akt signaling pathway
- Regulation of actin cytoskeleton
- Yersinia infection
Active Molecules (1,260)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DIZKXBOQGMAUNQ
|
10.7 | IC50 | 2 | — | |
FLCABSOQRLNJOS
|
10.4 | IC50 | 2 | — | |
OOYFOUHICCOHRQ
|
10.4 | IC50 | 2 | — | |
QPHITNQZXAUFEI
|
10.3 | IC50 | 2 | — | |
OIMQYWATTYNADK
|
10.3 | IC50 | 2 | — | |
GLJNHEQKGADNBQ
|
10.2 | IC50 | 2 | — | |
PRQQKDSSBGZCOL
|
10.2 | IC50 | 2 | — | |
QYLJBVNSXNPXCO
|
10.2 | IC50 | 2 | — | |
KANJDBFQNBEJPS
|
10.1 | IC50 | 2 | — | |
WIGSTHDXCOUXAO
|
10.1 | IC50 | 2 | — | |
GBQPAVGINXEHKX
|
10.1 | IC50 | 2 | — | |
JFSVPFIOVGIBHH
|
10.1 | IC50 | 2 | — | |
NYEPXWPYFSDIDX
|
10.1 | IC50 | 2 | — | |
QODRKUNYZZPWLY
|
10.1 | IC50 | 3 | — | |
HBHMXAWUVLNJOM
|
10.0 | IC50 | 2 | — | |
JUYLDRDBPRKGGI
|
10.0 | IC50 | 2 | — | |
NFLKOACGNNGCMZ
|
10.0 | IC50 | 2 | — | |
QLEPVYXTIMUWHF
|
10.0 | IC50 | 2 | — | |
RMGCKDRVLUITMO
|
10.0 | IC50 | 2 | — | |
RZDYGMVWRQQDRU
|
10.0 | IC50 | 2 | — | |
AEAYDNFPSLYSOA
|
10.0 | IC50 | 2 | — | |
MFMLIJVXQARVAA
|
10.0 | IC50 | 2 | — | |
AIALEJRVPVZVLO
|
9.9 | IC50 | 2 | — | |
BBLPBZKWFCDYOO
|
9.9 | IC50 | 2 | — | |
BFLDDNSQCPEXPM
|
9.8 | IC50 | 2 | — | |
HQJUSSKANCDJDV
|
9.8 | IC50 | 2 | — | |
JMYVXFQHQUNKFF
|
9.8 | IC50 | 2 | — | |
MZPKCSOECXTYLC
|
9.7 | IC50 | 2 | — | |
RDYYKKRRLZVNCE
|
9.7 | IC50 | 2 | — | |
IWJUFTWRMKICLP
|
9.7 | IC50 | 2 | — | |
MMYBBVWYPAIKBK
|
9.7 | IC50 | 2 | — | |
VEAVPXNJUXKCMP
|
9.7 | IC50 | 3 | — | |
HPTAYLDQFBSRPO
|
9.6 | IC50 | 2 | — | |
MTTOAAIJCSWQGQ
|
9.6 | IC50 | 2 | — | |
QDGGQCVCHRACBF
|
9.6 | IC50 | 2 | — | |
MLGBLCHXNBTYRD
|
9.6 | IC50 | 2 | — | |
NAHXFRKWBMENSV
|
9.6 | IC50 | 2 | — | |
PDYIZJZZAUFVHP
|
9.6 | IC50 | 2 | — | |
BDQBXEUFIFTAHI
|
9.5 | IC50 | 2 | — | |
CJSJCPSXRGQDKE
|
9.5 | IC50 | 2 | — | |
CJSJCPSXRGQDKE
|
9.5 | IC50 | 2 | — | |
ZNTZLEVMFVHFEN
|
9.5 | IC50 | 2 | — | |
QHVMOHLLRYTFPS
|
9.5 | IC50 | 2 | — | |
VPIVICLWCZPBIT
|
9.5 | IC50 | 3 | — | |
YDWCAPCMYPCFNI
|
9.5 | IC50 | 2 | — | |
NICNHDFNJXGGJV
|
9.5 | IC50 | 2 | — | |
UVGIBYJYUGXORP
|
9.5 | IC50 | 2 | — | |
SPYRCTMYBNFJRX
|
9.5 | IC50 | 3 | — | |
ZVYKWIXTSCOLQS
|
9.5 | IC50 | 2 | — | |
AMGNDOSLCFNDPI
|
9.5 | IC50 | 2 | — |