Target Details
| UniProt AC | P12931 |
|---|---|
| Gene Symbol | SRC |
| Protein Name | Proto-oncogene tyrosine-protein kinase Src |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,978
- Clinical molecules 816
- Avg pChEMBL 7.32
KEGG Pathways (45)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Bladder cancer
- C-type lectin receptor signaling pathway
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- GnRH signaling pathway
- Hepatitis B
- Herpes simplex virus 1 infection
- Hormone signaling
- Human cytomegalovirus infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Integrin signaling
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Mitophagy - animal
- Neutrophil extracellular trap formation
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Platelet activation
- Prolactin signaling pathway
- Proteoglycans in cancer
- Rap1 signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Thyroid hormone signaling pathway
- Tight junction
- Tuberculosis
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
Associated Diseases (2)
Active Molecules (1,978)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RBURTLAMOSHNGX
|
8.1 | IC50 | 4 | — | |
SMWGCUOXWXYZPF
|
8.1 | IC50 | 5 | — | |
VATOEUXNKZGEPM
|
8.1 | IC50 | 2 | — | |
WBBZJXHOJATBAX
|
8.1 | IC50 | 4 | — | |
WMVCBNJJXIOYAO
|
8.1 | IC50 | 4 | — | |
XXECVGSDNHEAMW
|
8.1 | IC50 | 4 | — | |
YDOGVCSSPRAZDJ
|
8.1 | IC50 | 4 | — | |
YIQDCOAZVWPXQA
|
8.1 | IC50 | 4 | — | |
DYHVAHJSHIYCLL
|
8.0 | IC50 | 4 | — | |
HTZNZEKPDCTESZ
|
8.0 | IC50 | 6 | Yes | |
ZPDSBOKGPBKXNQ
|
8.0 | IC50 | 4 | Yes | |
ICYGQSKHMTYUQT
|
8.0 | IC50 | 3 | — | |
DJCLBOJZORFUMR
|
8.0 | IC50 | 2 | — | |
HRRMXIICSWVXIS
|
8.0 | IC50 | 13 | Yes | |
WMWHVTDZNIVNIE
|
8.0 | IC50 | 9 | — | |
WMWHVTDZNIVNIE
|
8.0 | IC50 | 9 | — | |
AMKNQROTNAOJQE
|
8.0 | IC50 | 7 | — | |
ARVCFDUHKZCQJL
|
8.0 | IC50 | 3 | — | |
BSGXDJPCRLBTKU
|
8.0 | IC50 | 3 | — | |
BUUXCZKMEAGSSK
|
8.0 | IC50 | 3 | — | |
BWVGZIFGIUHNAE
|
8.0 | IC50 | 4 | — | |
BZUNLTWIUMVYTM
|
8.0 | IC50 | 2 | — | |
CHPHDLQQSCKHOK
|
8.0 | IC50 | 8 | Yes | |
CQZZCFVTEOJWAW
|
8.0 | IC50 | 5 | Yes | |
FIHAXQZQWYILHF
|
8.0 | IC50 | 2 | — | |
HHONORFVXLXKEB
|
8.0 | IC50 | 3 | — | |
IFLRTIBATNZOEH
|
8.0 | IC50 | 4 | — | |
KAUYVUREAPHUSF
|
8.0 | IC50 | 5 | Yes | |
KFTIUYWZCYZUGD
|
8.0 | IC50 | 3 | — | |
MIMOHMCANSGXIG
|
8.0 | IC50 | 15 | — | |
MISJXJNFFYOIPX
|
8.0 | IC50 | 2 | — | |
NZIUKWCXTXDJLH
|
8.0 | IC50 | 4 | — | |
OSKCQZJVUYDWFX
|
8.0 | IC50 | 2 | Yes | |
QWQMRUMSNDKCQI
|
8.0 | IC50 | 2 | — | |
RQVLOUXWVWPIMN
|
8.0 | IC50 | 3 | — | |
SBLMCLDRWJNEJK
|
8.0 | IC50 | 17 | — | |
TVNZRDDQMBWCDE
|
8.0 | IC50 | 3 | — | |
UEFUTYVFNURZNH
|
8.0 | IC50 | 3 | — | |
UFKINFUUYHPLQS
|
8.0 | IC50 | 3 | — | |
UUXGWAWTZHFHHC
|
8.0 | Ki | 2 | — | |
VFCRJQKABYQLDB
|
8.0 | IC50 | 3 | — | |
VZEBZVKYQRSFDD
|
8.0 | IC50 | 3 | — | |
WEACIVJSLZZZLC
|
8.0 | IC50 | 3 | — | |
WIGUVQBLQNQDPX
|
8.0 | IC50 | 2 | Yes | |
WPOXAFXHRJYEIC
|
8.0 | IC50 | 2 | Yes | |
WRKCCXCCDUYPLU
|
8.0 | IC50 | 3 | — | |
WXUNFLPVNBQMNX
|
8.0 | IC50 | 3 | — | |
YEXAEGWRSZOFGW
|
8.0 | IC50 | 4 | — | |
YOKSFKATMBKCHB
|
8.0 | IC50 | 4 | Yes | |
ZLMVXCGWUJXFNP
|
8.0 | IC50 | 15 | Yes |