Target Details
UniProt ACP11387
Gene SymbolTOP1
Protein NameDNA topoisomerase 1
OrganismHomo sapiens
Entry Name
Organism Category Human
Pfam Domains PF14370 (Topo_C_assoc) PF01028 (Topoisom_I) PF02919 (Topoisom_I_N)
Summary
  • Multi-target molecules 6
  • Clinical molecules 0
  • Avg pChEMBL 7.11
Top Co-occurrence Targets
Active Molecules (6)
InChIKey pChEMBL Type Targets Clinical
MWKSRKSEWLRPBL 8.2 Kd 1075
RPFYDENHBPRCTN 7.5 IC50 2
AJTBUWMKUOLMNM 7.4 IC50 5
ZCCPLJOKGAACRT 7.4 Kd 599
VSJKWCGYPAHWDS 6.2 IC50 19
FJHBVJOVLFPMQE 6.0 IC50 2
2D structure