Target Details
| UniProt AC | P11215 |
|---|---|
| Gene Symbol | ITGAM |
| Protein Name | Integrin alpha-M |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01839 (FG-GAP) PF08441 (Integrin_A_Ig_1) PF20805 (Integrin_A_Ig_2) PF00357 (Integrin_alpha) PF21520 (ITGAX-like_Ig_3) PF00092 (VWA) |
Summary
- Multi-target molecules 2
- Clinical molecules 0
- Avg pChEMBL 6.92
KEGG Pathways (18)
- Acute myeloid leukemia
- Amoebiasis
- Cell adhesion molecule (CAM) interaction
- Complement and coagulation cascades
- Hematopoietic cell lineage
- IgSF CAM signaling
- Integrin signaling
- Legionellosis
- Leishmaniasis
- Leukocyte transendothelial migration
- Neutrophil extracellular trap formation
- Pertussis
- Phagosome
- Rap1 signaling pathway
- Regulation of actin cytoskeleton
- Staphylococcus aureus infection
- Transcriptional misregulation in cancer
- Tuberculosis
Active Molecules (2)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QIUVOSJLYMTVAE
|
7.3 | IC50 | 5 | — | |
FXYDXLJEJBXFBD
|
6.5 | IC50 | 5 | — |