Target Details
| UniProt AC | P10398 |
|---|---|
| Gene Symbol | ARAF |
| Protein Name | Serine/threonine-protein kinase A-Raf |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF07714 (PK_Tyr_Ser-Thr) PF02196 (RBD) |
Summary
- Multi-target molecules 37
- Clinical molecules 1
- Avg pChEMBL 7.4
KEGG Pathways (36)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Bladder cancer
- Breast cancer
- Chemical carcinogenesis - reactive oxygen species
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanoma
- Natural killer cell mediated cytotoxicity
- Non-small cell lung cancer
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Progesterone-mediated oocyte maturation
- Prostate cancer
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Serotonergic synapse
- Vascular smooth muscle contraction
Associated Diseases (1)
Active Molecules (37)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YXARVHZXTQVAOP
|
9.0 | IC50 | 11 | — | |
GPXBXXGIAQBQNI
|
8.7 | IC50 | 11 | — | |
GZMYLSJUNSCMTD
|
8.6 | IC50 | 4 | — | |
YAMDBYWVYODFIX
|
8.3 | IC50 | 2 | — | |
ZCRCSVOTXUZYDS
|
8.3 | IC50 | 2 | — | |
NGFFVZQXSRKHBM
|
8.2 | IC50 | 3 | — | |
MLDQJTXFUGDVEO
|
8.2 | IC50 | 85 | Yes | |
JLJLHDXHENENSD
|
8.1 | IC50 | 3 | — | |
LMXYVLFTZRPNRV
|
7.8 | IC50 | 7 | — | |
LMXYVLFTZRPNRV
|
7.8 | IC50 | 8 | — | |
KGBGFESWRCPKLE
|
7.7 | IC50 | 3 | — | |
GZCIDSUBIQFYQY
|
7.6 | IC50 | 3 | — | |
UKNVYAQQWQVCTL
|
7.6 | IC50 | 3 | — | |
BFSMGDJOXZAERB
|
7.6 | IC50 | 33 | — | |
CZUGFURKAUPQAE
|
7.5 | IC50 | 3 | — | |
ACGNJFZSGIKELN
|
7.5 | IC50 | 3 | — | |
UZPXHYLFKLVCPZ
|
7.5 | IC50 | 3 | — | |
MQRBGJVORNPGNX
|
7.4 | IC50 | 3 | — | |
IDIZGFUDIPHVLQ
|
7.4 | IC50 | 3 | — | |
LKMCVOPCAQBIKI
|
7.4 | IC50 | 3 | — | |
HHCBMISMPSAZBF
|
7.4 | IC50 | 23 | — | |
QXZUOAMZKBWIEJ
|
7.4 | IC50 | 3 | — | |
AYQHOBZHSKGYBW
|
7.3 | IC50 | 3 | — | |
DQCLAIYABKFDCU
|
7.3 | IC50 | 3 | — | |
MHYLKHNGFDIZID
|
7.2 | IC50 | 3 | — | |
FECGNZAYTJHJIY
|
7.0 | IC50 | 3 | — | |
WMVXSEQUHAGMDB
|
6.9 | IC50 | 3 | — | |
KVCQTKNUUQOELD
|
6.8 | IC50 | 6 | — | |
WHMDUJXKQMEJCM
|
6.7 | IC50 | 3 | — | |
OUNQRCDSRRWMKW
|
6.7 | IC50 | 3 | — | |
PBQDGEKTDHPEJT
|
6.7 | IC50 | 3 | — | |
WVXNSAVVKYZVOE
|
6.6 | IC50 | 92 | — | |
NMFQZWVFUOSAGD
|
6.5 | IC50 | 2 | — | |
OBXGMXIUFAXGAZ
|
6.5 | IC50 | 2 | — | |
UEPXBTCUIIGYCY
|
6.4 | IC50 | 6 | — | |
BICWYVYJYVUJSQ
|
6.1 | IC50 | 2 | — | |
IKLRBEWSNVBCHQ
|
6.0 | IC50 | 15 | — |