Target Details
| UniProt AC | P10145 |
|---|---|
| Gene Symbol | CXCL8 |
| Protein Name | Interleukin-8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00048 (IL8) |
Summary
- Multi-target molecules 9
- Clinical molecules 1
- Avg pChEMBL 7.26
KEGG Pathways (33)
- AGE-RAGE signaling pathway in diabetic complications
- Alcoholic liver disease
- Amoebiasis
- Bladder cancer
- Cellular senescence
- Chagas disease
- Chemokine signaling pathway
- Coronavirus disease - COVID-19
- Cytokine-cytokine receptor interaction
- Epithelial cell signaling in Helicobacter pylori infection
- Hepatitis B
- Human cytomegalovirus infection
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Legionellosis
- Lipid and atherosclerosis
- Malaria
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Non-alcoholic fatty liver disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pertussis
- Phospholipase D signaling pathway
- RIG-I-like receptor signaling pathway
- Rheumatoid arthritis
- Salmonella infection
- Shigellosis
- Toll-like receptor signaling pathway
- Transcriptional misregulation in cancer
- Viral protein interaction with cytokine and cytokine receptor
- Yersinia infection
Active Molecules (9)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DCOPUUMXTXDBNB
|
8.1 | IC50 | 5 | — | |
HKSWAIDHHZHZTD
|
7.8 | IC50 | 6 | — | |
DKYWVDODHFEZIM
|
7.7 | IC50 | 3 | — | |
DTFJTXRGYIXMMS
|
7.6 | IC50 | 5 | — | |
CGIGDMFJXJATDK
|
7.3 | IC50 | 11 | Yes | |
HEFNNWSXXWATRW
|
7.3 | IC50 | 3 | — | |
UPSPUYADGBWSHF
|
7.0 | IC50 | 3 | — | |
GZRAEWKMFPWXNW
|
6.3 | IC50 | 2 | — | |
SRFABRWQVPCPRG
|
6.2 | IC50 | 3 | — |