Target Details
| UniProt AC | P0DP23 |
|---|---|
| Gene Symbol | CALM1 |
| Protein Name | Calmodulin-1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF13499 (EF-hand_7) |
Summary
- Multi-target molecules 8
- Clinical molecules 0
- Avg pChEMBL 6.35
KEGG Pathways (43)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amphetamine addiction
- Apelin signaling pathway
- C-type lectin receptor signaling pathway
- Calcium signaling pathway
- Cellular senescence
- Circadian entrainment
- Dopaminergic synapse
- Estrogen signaling pathway
- Fluid shear stress and atherosclerosis
- Gastric acid secretion
- Glioma
- Glucagon signaling pathway
- GnRH signaling pathway
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Inflammatory mediator regulation of TRP channels
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Long-term potentiation
- Melanogenesis
- Neurotrophin signaling pathway
- Olfactory transduction
- Oocyte meiosis
- Oxytocin signaling pathway
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Phosphatidylinositol signaling system
- Phototransduction
- Rap1 signaling pathway
- Ras signaling pathway
- Renin secretion
- Salivary secretion
- Tuberculosis
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (2)
Active Molecules (8)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZCCPLJOKGAACRT
|
7.0 | Kd | 599 | — | |
MWKSRKSEWLRPBL
|
6.7 | Kd | 1075 | — | |
XWTMXXXVLLXRMT
|
6.6 | IC50 | 2 | — | |
JLUUJHIQVIXTGT
|
6.3 | IC50 | 2 | — | |
CQJBJVJROJYMEM
|
6.1 | IC50 | 2 | — | |
DTEYDGIWCYPJMI
|
6.1 | IC50 | 2 | — | |
WDTZTWNUHSPIIX
|
6.0 | IC50 | 2 | — | |
ZEWQUBUPAILYHI
|
6.0 | Kd | 21 | — |