Target Details
| UniProt AC | P08684 |
|---|---|
| Gene Symbol | CYP3A4 |
| Protein Name | Cytochrome P450 3A4 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00067 (p450) |
Summary
- Multi-target molecules 851
- Clinical molecules 17
- Avg pChEMBL 6.65
KEGG Pathways (10)
- Bile secretion
- Chemical carcinogenesis - DNA adducts
- Chemical carcinogenesis - receptor activation
- Drug metabolism - cytochrome P450
- Drug metabolism - other enzymes
- Linoleic acid metabolism
- Metabolic pathways
- Metabolism of xenobiotics by cytochrome P450
- Retinol metabolism
- Steroid hormone biosynthesis
Associated Diseases (1)
Active Molecules (851)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
PNCYZOJJIHDBQW
|
10.7 | Ki | 2 | — | |
MXRXLBDXLGOZNC
|
10.6 | Ki | 2 | — | |
JVBGVXAXEZXWTE
|
10.3 | IC50 | 2 | — | |
HMKAZNCSHAJLSA
|
10.0 | IC50 | 3 | — | |
IHUMWHKQAVMWCV
|
10.0 | IC50 | 2 | — | |
QGOICCMBEDDFCI
|
9.5 | IC50 | 2 | — | |
MFFQPYYPGSJIDM
|
9.4 | IC50 | 2 | — | |
LVOHHKIFPDWJJY
|
9.3 | IC50 | 2 | — | |
VZGOJYYBQQYRJE
|
9.3 | IC50 | 2 | — | |
KCSXXVMVRJMJFA
|
9.2 | IC50 | 2 | — | |
OQEBLEZRSCIFJK
|
9.2 | IC50 | 2 | — | |
NKJTYXXPGXIGTL
|
9.1 | IC50 | 2 | — | |
DWDATRBHPMAHRD
|
9.1 | IC50 | 2 | — | |
OCNLJCSEDBMGNF
|
9.1 | IC50 | 2 | — | |
HPVDZWIMLRMLSJ
|
9.0 | IC50 | 4 | — | |
PAIPLWPUQXJMMT
|
9.0 | IC50 | 4 | — | |
AZFITEALNSCCOH
|
9.0 | IC50 | 2 | — | |
CETJSTBZOJQTPJ
|
9.0 | IC50 | 2 | — | |
DWHFXDLHZUPSDA
|
9.0 | IC50 | 2 | — | |
GVPOBQMDDUCYKM
|
9.0 | IC50 | 2 | — | |
MTUYBYGTWUVARZ
|
9.0 | IC50 | 2 | — | |
UFGROHQRASPGIZ
|
9.0 | IC50 | 2 | — | |
DOLFOQBBXQXIND
|
8.9 | Ki | 4 | — | |
OMEGCBMNQDIBMF
|
8.9 | IC50 | 2 | — | |
GRQYMCJQVKMJAT
|
8.8 | IC50 | 4 | — | |
KLCHUAUMSZUJEX
|
8.8 | IC50 | 5 | Yes | |
FTKTXHIRMKWXBE
|
8.8 | IC50 | 2 | — | |
MANSWCXFKVIKPE
|
8.7 | IC50 | 2 | — | |
XWUXNFBFVBWTFY
|
8.7 | IC50 | 2 | — | |
NNHVHOSSHPGFHJ
|
8.7 | IC50 | 2 | — | |
AHPTUXAIRHFFGA
|
8.6 | IC50 | 2 | — | |
LJVAJPDWBABPEJ
|
8.6 | Ki | 59 | — | |
ZJATUHGFXPEBQJ
|
8.6 | IC50 | 2 | — | |
ILKQWXHVEJRPAL
|
8.6 | IC50 | 2 | — | |
WCIIYKWDVLHGIY
|
8.5 | IC50 | 2 | — | |
VVICOEQHILEAPE
|
8.5 | IC50 | 2 | — | |
DRQNCWQLZYUQOI
|
8.5 | IC50 | 2 | — | |
HEBKCUAEAWNUQL
|
8.4 | IC50 | 2 | — | |
GMYMOUHNOWZKMI
|
8.4 | IC50 | 2 | — | |
ZCFKCDRXDKIAQV
|
8.4 | IC50 | 2 | — | |
ANBSWCCVJMJABF
|
8.4 | IC50 | 2 | — | |
DQVDXXLRESFSRM
|
8.4 | IC50 | 5 | — | |
JKKIQRNCGVRLBH
|
8.3 | IC50 | 2 | — | |
JLCRPHKUMRKGFQ
|
8.3 | IC50 | 4 | — | |
WQQQUDROKZMYJS
|
8.3 | Ki | 4 | — | |
RXIYTLYKWJVLSP
|
8.3 | IC50 | 3 | — | |
CFXKXVRFVROHAJ
|
8.2 | IC50 | 2 | — | |
FDQOBNRCVYTPOK
|
8.2 | Ki | 4 | — | |
NZOONKHCNQFYCI
|
8.2 | IC50 | 5 | — | |
SZTUUDCVQNNFRD
|
8.2 | IC50 | 2 | — |