Target Details
| UniProt AC | P08581 |
|---|---|
| Gene Symbol | MET |
| Protein Name | Hepatocyte growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF01437 (PSI) PF01403 (Sema) PF01833 (TIG) |
Summary
- Multi-target molecules 1,125
- Clinical molecules 162
- Avg pChEMBL 7.37
KEGG Pathways (25)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Transcriptional misregulation in cancer
Associated Diseases (8)
Active Molecules (1,125)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MBSLAWMYDOHYMD
|
7.8 | IC50 | 2 | — | |
MYPQPZOTEGVVQY
|
7.8 | IC50 | 3 | — | |
OFOCUZOOTYLYIC
|
7.8 | IC50 | 2 | — | |
OVKBEVSXNZKSNI
|
7.8 | IC50 | 2 | — | |
SYBBQHFEZCTVCZ
|
7.8 | pIC50 | 2 | Yes | |
XMKAFTZMVDNUII
|
7.8 | IC50 | 2 | — | |
YHNFDTDPUBTIIP
|
7.8 | pIC50 | 2 | Yes | |
GGJPKPHOWZDYAP
|
7.8 | IC50 | 2 | — | |
AYNVIPPTDMPZRW
|
7.8 | IC50 | 2 | — | |
XUNJDJYWLQEZOG
|
7.8 | IC50 | 2 | — | |
FSIJKYVPVCJWQB
|
7.7 | IC50 | 2 | — | |
MDUIZYSXKRMPCO
|
7.7 | IC50 | 2 | — | |
PNZXGVDDWVRAON
|
7.7 | pIC50 | 2 | Yes | |
VDNNDJSNBJTEFQ
|
7.7 | IC50 | 2 | — | |
VFEZANCUVFZYLF
|
7.7 | IC50 | 2 | — | |
XFXAMCQJMNCCHZ
|
7.7 | IC50 | 2 | — | |
XRRMNZJUZRPHGN
|
7.7 | IC50 | 2 | — | |
FVIIFUOCWXBFMO
|
7.7 | pIC50 | 2 | Yes | |
FXDWNCFVVOSWKM
|
7.7 | pIC50 | 5 | Yes | |
GYHVOCADFBWUEX
|
7.7 | IC50 | 2 | — | |
JPWGMNSPCZZICA
|
7.7 | IC50 | 4 | — | |
KNYXCJCIVARQRW
|
7.7 | pIC50 | 2 | Yes | |
PIRWRQQYRXWTII
|
7.7 | IC50 | 3 | — | |
VCKUIQTVATWJTK
|
7.7 | IC50 | 3 | — | |
VQYYQSZNRVQLIS
|
7.7 | IC50 | 3 | — | |
ZDNWBLXKFNBSDR
|
7.7 | pIC50 | 3 | Yes | |
BCAVINCFLAMRMW
|
7.7 | IC50 | 2 | — | |
AMVSPCWTSDZDPI
|
7.7 | IC50 | 2 | — | |
FPYJSJDOHRDAMT
|
7.7 | IC50 | 4 | — | |
FVWWFRASLMZWEX
|
7.7 | pIC50 | 2 | Yes | |
GNPAAWCPMQVWOZ
|
7.7 | pIC50 | 2 | Yes | |
HPCRKJXLHNPYNB
|
7.7 | pIC50 | 2 | Yes | |
IGPDFRGHANCKMA
|
7.7 | IC50 | 2 | — | |
LFEDLHADEYEZAN
|
7.7 | IC50 | 2 | — | |
NQLLIQIRTXVXRX
|
7.7 | pIC50 | 2 | Yes | |
PKVZAVOIHKTALW
|
7.7 | IC50 | 2 | — | |
SIAHWSSTPPXGSH
|
7.7 | IC50 | 2 | — | |
WLAVZAAODLTUSW
|
7.7 | IC50 | 7 | — | |
XBYVOPRDASFDMY
|
7.7 | Ki | 42 | — | |
YKKMSYLSEXFJCA
|
7.7 | IC50 | 2 | — | |
MPVXOIXRPUPSAK
|
7.7 | IC50 | 2 | — | |
AHFOPBCHPBMFCI
|
7.7 | IC50 | 2 | — | |
FQIRYXKZWMEKES
|
7.7 | IC50 | 8 | — | |
HTKBLUVWSMOXQU
|
7.7 | IC50 | 2 | — | |
IMLPTVNOQPZHSM
|
7.7 | IC50 | 2 | — | |
ISPBCAXOSOLFME
|
7.7 | IC50 | 11 | — | |
KHBUKOVUBUJCGM
|
7.7 | IC50 | 2 | — | |
SXBRUEVGWHKYKR
|
7.7 | IC50 | 2 | — | |
IBWQJAQFQVORMS
|
7.7 | Ki | 2 | — | |
MRPVSLYDNAEONA
|
7.7 | IC50 | 2 | — |