Target Details
| UniProt AC | P08581 |
|---|---|
| Gene Symbol | MET |
| Protein Name | Hepatocyte growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF01437 (PSI) PF01403 (Sema) PF01833 (TIG) |
Summary
- Multi-target molecules 1,125
- Clinical molecules 162
- Avg pChEMBL 7.37
KEGG Pathways (25)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Transcriptional misregulation in cancer
Associated Diseases (8)
Active Molecules (1,125)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YMFWEIKNDBLHIR
|
8.1 | IC50 | 3 | — | |
LUAWSFFQLRPDPM
|
8.1 | IC50 | 3 | — | |
UEPPBJWMOQEIAS
|
8.1 | IC50 | 2 | — | |
WLMNKPZFGDGAIG
|
8.1 | IC50 | 2 | — | |
HEAIZQNMNCHNFD
|
8.1 | IC50 | 3 | — | |
IVVJTHXSXYVDOH
|
8.1 | pIC50 | 2 | Yes | |
JTRYIRPUUMAXSL
|
8.1 | pIC50 | 2 | Yes | |
KEGATCOFPMKYRA
|
8.1 | pIC50 | 4 | Yes | |
MXQDRRGPOHEUMT
|
8.1 | IC50 | 2 | — | |
OHUNADGDEWQCLI
|
8.1 | IC50 | 2 | — | |
OYONTEXKYJZFHA
|
8.1 | IC50 | 69 | Yes | |
PEGWVOKOYYAQEV
|
8.1 | IC50 | 9 | — | |
DUOXXYBVQYYLOV
|
8.0 | IC50 | 2 | — | |
IRODQIAZONZCDC
|
8.0 | IC50 | 2 | — | |
JGEBLDKNWBUGRZ
|
8.0 | pIC50 | 20 | Yes | |
QACCVOJRKKIYFM
|
8.0 | IC50 | 3 | — | |
VEAHCSCQSILXPX
|
8.0 | IC50 | 2 | — | |
YMFBMICXJMUQNQ
|
8.0 | IC50 | 2 | — | |
GODJFMYOWZKKJA
|
8.0 | IC50 | 2 | — | |
OJKSOMBYZCPNMD
|
8.0 | IC50 | 2 | — | |
VFFLZADJYBSNMH
|
8.0 | IC50 | 2 | — | |
AROLGHDKPPHEQG
|
8.0 | pIC50 | 2 | Yes | |
CTSDMCNSBRVZGJ
|
8.0 | IC50 | 2 | — | |
HCPGIKXNSDXVKD
|
8.0 | pIC50 | 2 | Yes | |
HNDZJFGTHKMGAS
|
8.0 | IC50 | 3 | — | |
KNARVZUUCLIBGV
|
8.0 | Ki | 33 | — | |
LDYZXHSJFDQENC
|
8.0 | IC50 | 2 | — | |
MMRWFYJZBLPXLP
|
8.0 | pIC50 | 2 | Yes | |
NJPZYQYDYUEVPF
|
8.0 | IC50 | 3 | — | |
OHLUERTUZNIQEE
|
8.0 | IC50 | 2 | — | |
VCFDMLBPASGZTP
|
8.0 | Ki | 38 | — | |
VOFRHOICPASWQC
|
8.0 | IC50 | 2 | — | |
YLOWYMLGKQEHQR
|
8.0 | pIC50 | 2 | Yes | |
ZXXJTQRLPRCGMZ
|
8.0 | pIC50 | 2 | Yes | |
VQYHPUHKYSSEOB
|
8.0 | IC50 | 5 | — | |
LKHBLJXMYCTBJQ
|
8.0 | IC50 | 2 | — | |
HYDSSXBBNYALNP
|
8.0 | IC50 | 5 | — | |
KPPTZOUOPSHOGH
|
8.0 | pIC50 | 2 | Yes | |
LFDJFILTWUNEEP
|
8.0 | pIC50 | 6 | Yes | |
OWHNQRWVPROBIY
|
8.0 | pIC50 | 2 | Yes | |
XNRABRXYGRUDAX
|
8.0 | IC50 | 3 | — | |
YKCLPZQBFQBZAH
|
8.0 | IC50 | 2 | — | |
IHKWHSZSPBFQEP
|
7.9 | IC50 | 3 | — | |
OWJRWSURUBTCKB
|
7.9 | IC50 | 2 | — | |
NLEDHYBQBOGUPV
|
7.9 | pIC50 | 2 | Yes | |
NUQNIAPGIBNTJZ
|
7.9 | IC50 | 2 | — | |
RIXXXEWTJFUQDB
|
7.9 | pIC50 | 2 | Yes | |
RJPWJBZOGOJRIA
|
7.9 | IC50 | 2 | — | |
UYJWJPAEASSWOT
|
7.9 | pIC50 | 2 | Yes | |
VLSRGLWQHNMOLJ
|
7.9 | IC50 | 3 | — |