Target Details
| UniProt AC | P08581 |
|---|---|
| Gene Symbol | MET |
| Protein Name | Hepatocyte growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF01437 (PSI) PF01403 (Sema) PF01833 (TIG) |
Summary
- Multi-target molecules 1,125
- Clinical molecules 162
- Avg pChEMBL 7.37
KEGG Pathways (25)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Transcriptional misregulation in cancer
Associated Diseases (8)
Active Molecules (1,125)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KBRRUGLLZHVECV
|
8.6 | IC50 | 2 | — | |
UFWJGUUHERHCOL
|
8.6 | IC50 | 3 | — | |
HFSWCNDZVPIIOF
|
8.6 | IC50 | 8 | — | |
GNNDEPIMDAZHRQ
|
8.6 | IC50 | 6 | — | |
UYMSIPINLJNNOU
|
8.6 | IC50 | 4 | — | |
HSCXFZRWWNVICY
|
8.6 | IC50 | 2 | — | |
MSARFVPGJQLYDU
|
8.6 | IC50 | 2 | — | |
PQNIGFMNUHDZKX
|
8.5 | IC50 | 4 | — | |
QCKKTDVCCCBGDD
|
8.5 | IC50 | 8 | — | |
QKVFMAAIXZONRN
|
8.5 | IC50 | 2 | — | |
WCKQZMCXHJVIQF
|
8.5 | IC50 | 2 | — | |
BGHOGQNFMBHPKJ
|
8.5 | pIC50 | 2 | Yes | |
CVUXIABNRCIXRF
|
8.5 | pIC50 | 2 | Yes | |
CXDZGSNFZYGQSZ
|
8.5 | pIC50 | 4 | Yes | |
HGHDKUIVPHCCKQ
|
8.5 | IC50 | 2 | — | |
IEQYRWPMNVPDLX
|
8.5 | IC50 | 2 | — | |
JRWCBEOAFGHNNU
|
8.5 | IC50 | 3 | — | |
QQWUGDVOUVUTOY
|
8.5 | pIC50 | 231 | Yes | |
WINHZLLDWRZWRT
|
8.5 | pIC50 | 201 | Yes | |
AHYMHWXQRWRBKT
|
8.5 | IC50 | 2 | — | |
ZIEVFEZSDLFCCS
|
8.5 | IC50 | 2 | — | |
ULMCFLZUGRSEQA
|
8.5 | Ki | 17 | — | |
VMJFTOSOFDEKTM
|
8.5 | IC50 | 2 | — | |
HKGJCZLDFIJHIO
|
8.5 | IC50 | 2 | — | |
VIIXGCDJLIQYIW
|
8.5 | IC50 | 2 | — | |
UVNDVSUMHWZESZ
|
8.5 | Ki | 8 | Yes | |
UVWUQSHODAJLLX
|
8.5 | IC50 | 2 | — | |
IRHRCZXPBGNLKK
|
8.4 | IC50 | 2 | — | |
ONIQOQHATWINJY
|
8.4 | IC50 | 25 | — | |
QPKFJNSFZBUDOA
|
8.4 | IC50 | 2 | — | |
CTSDMCNSBRVZGJ
|
8.4 | IC50 | 2 | — | |
OWTPWQUSKAAQEF
|
8.4 | IC50 | 2 | — | |
CYWYLXHLHZXEMX
|
8.4 | IC50 | 2 | — | |
LKMOAEYSAVVRPZ
|
8.4 | IC50 | 2 | — | |
LWVKBWDPQJMBIE
|
8.4 | IC50 | 2 | — | |
VTEOGOHIPGCAQW
|
8.4 | IC50 | 2 | — | |
BCZUAADEACICHN
|
8.4 | IC50 | 3 | — | |
DPSHYRRSRHVRRE
|
8.4 | IC50 | 2 | — | |
SHNNJOOHYANVQG
|
8.4 | IC50 | 2 | — | |
VNBRGSXVFBYQNN
|
8.4 | IC50 | 22 | Yes | |
XHIQDQUOOKVPRP
|
8.4 | IC50 | 4 | — | |
BRTHUECZMVKNMQ
|
8.4 | Ki | 31 | — | |
GVVAOKGDOGVPSI
|
8.4 | IC50 | 2 | — | |
HVCCYRAHPMMFKT
|
8.4 | IC50 | 2 | — | |
KTEIFNKAUNYNJU
|
8.4 | IC50 | 114 | — | |
NVMDAZMLLHNPND
|
8.4 | IC50 | 2 | — | |
OSHPEWCCDRPGGK
|
8.4 | IC50 | 3 | — | |
QMEPZWHCBROEIB
|
8.4 | pIC50 | 2 | Yes | |
QRWHTFXNHZLJAL
|
8.4 | IC50 | 5 | — | |
WPHKIQPVPYJNAX
|
8.4 | Ki | 81 | — |