Target Details
| UniProt AC | P08581 |
|---|---|
| Gene Symbol | MET |
| Protein Name | Hepatocyte growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF01437 (PSI) PF01403 (Sema) PF01833 (TIG) |
Summary
- Multi-target molecules 1,125
- Clinical molecules 162
- Avg pChEMBL 7.37
KEGG Pathways (25)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Transcriptional misregulation in cancer
Associated Diseases (8)
Active Molecules (1,125)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZYSDOHJQCLKJEV
|
6.3 | IC50 | 2 | — | |
IABQJUAIUTYRSV
|
6.2 | IC50 | 2 | — | |
LPCWRKLTAPXZDQ
|
6.2 | IC50 | 2 | — | |
OMVAYCDDPIHBDR
|
6.2 | IC50 | 5 | — | |
XXJWYDDUDKYVKI
|
6.2 | Kd | 52 | — | |
DGKPSIOJHHBXOP
|
6.2 | IC50 | 3 | — | |
RFKWZWJQRQCLJF
|
6.2 | IC50 | 2 | — | |
ZYDPMGJUGLYACC
|
6.2 | IC50 | 2 | — | |
AQRHXRWJOUUDKH
|
6.2 | IC50 | 2 | — | |
CFIBXVQLBVNOHW
|
6.2 | Ki | 64 | — | |
HRZOUBQYVUXBNS
|
6.2 | Ki | 38 | — | |
JMIIFJIJWDCOEP
|
6.2 | Ki | 15 | — | |
JNXJKTXDSPWNRP
|
6.2 | Ki | 30 | — | |
NRGYZNJPCGRCLV
|
6.2 | Ki | 52 | — | |
PTVPBWWDGZSEAF
|
6.2 | Ki | 63 | — | |
VYPMKWZQENSPAB
|
6.2 | Ki | 3 | — | |
KDKUVYLMPJIGKA
|
6.2 | Kd | 91 | Yes | |
FYWNSODYJWGXTK
|
6.2 | IC50 | 2 | — | |
AEXYDYPBGQQOMN
|
6.2 | IC50 | 2 | — | |
GCIKSSRWRFVXBI
|
6.2 | Kd | 109 | Yes | |
GUBJNPWVIUFSTR
|
6.2 | Kd | 103 | — | |
UOHFAMGTXFZOIS
|
6.2 | IC50 | 2 | — | |
WXVJFRUQXJHDPY
|
6.2 | pIC50 | 4 | Yes | |
ZJROCJVDMHFPBR
|
6.2 | pIC50 | 4 | Yes | |
ATJORKOQGVNLQY
|
6.2 | IC50 | 2 | — | |
AWJXWMJXQDNNHI
|
6.2 | IC50 | 3 | — | |
AYAAYSFAENPXLJ
|
6.2 | IC50 | 3 | — | |
BBPZXJMNEQEUBK
|
6.2 | IC50 | 2 | — | |
BJHLJRKGOCSNAB
|
6.2 | IC50 | 2 | — | |
BMGQWWVMWDBQGC
|
6.2 | Kd | 147 | Yes | |
BMGQWWVMWDBQGC
|
6.2 | Kd | 91 | Yes | |
CWVXEQPXRFPKEZ
|
6.2 | IC50 | 2 | — | |
DZKHRKMBAPEIOK
|
6.2 | IC50 | 2 | — | |
FSVJWBPBIXGNJR
|
6.2 | IC50 | 2 | — | |
FTBWNMAFKFLFHP
|
6.2 | IC50 | 2 | — | |
GCEHBYASKOQVGC
|
6.2 | IC50 | 2 | — | |
GJLXMTNNDQGGKD
|
6.2 | IC50 | 2 | — | |
GQLITRCSLFCUTG
|
6.2 | IC50 | 2 | — | |
HGDSJOVHQLLMOS
|
6.2 | IC50 | 2 | — | |
HOIBJSHJRQULFL
|
6.2 | IC50 | 3 | — | |
IMTPDXPBIHKJMT
|
6.2 | IC50 | 2 | — | |
JESGNXZGLBLJDC
|
6.2 | IC50 | 2 | — | |
LHMYKWTXKYBYKY
|
6.2 | IC50 | 2 | — | |
MPVGZUGXCQEXTM
|
6.2 | Kd | 61 | Yes | |
NWOWRWKOTHXMFN
|
6.2 | IC50 | 2 | — | |
ONOSFELSQUOGIC
|
6.2 | IC50 | 3 | — | |
QPXKLICOIXEZHL
|
6.2 | IC50 | 2 | — | |
QUGMULQJKFZKBO
|
6.2 | IC50 | 3 | — | |
RBGWDTGTACCPGE
|
6.2 | IC50 | 2 | — | |
SIISCDRBPBFCTB
|
6.2 | IC50 | 2 | — |