Target Details
| UniProt AC | P08581 |
|---|---|
| Gene Symbol | MET |
| Protein Name | Hepatocyte growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF01437 (PSI) PF01403 (Sema) PF01833 (TIG) |
Summary
- Multi-target molecules 1,125
- Clinical molecules 162
- Avg pChEMBL 7.37
KEGG Pathways (25)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Transcriptional misregulation in cancer
Associated Diseases (8)
Active Molecules (1,125)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NKEUPUJTVALZIK
|
6.5 | Ki | 28 | — | |
NWMPVMMGSHXANZ
|
6.5 | Ki | 58 | — | |
UQNNJYLAPYGZBD
|
6.5 | Ki | 28 | — | |
VSVWQTDDGQSGHP
|
6.5 | Ki | 51 | — | |
SNYQSPGQFDKITH
|
6.5 | IC50 | 3 | — | |
YUEIVZVKVPTLKP
|
6.5 | IC50 | 2 | — | |
DXASYTJLINRTNC
|
6.5 | IC50 | 4 | — | |
PATWJULQBOCIBW
|
6.5 | IC50 | 2 | — | |
XZXHXSATPCNXJR
|
6.5 | Kd | 165 | Yes | |
YRQIZIMDOXXDDC
|
6.5 | IC50 | 2 | — | |
MBDXRRFVBRTNPY
|
6.5 | IC50 | 2 | — | |
MBWDNCFTSFBVMY
|
6.5 | IC50 | 2 | — | |
FBTKKBCORZJIFB
|
6.5 | IC50 | 2 | — | |
SLEWGGZPOQNVSU
|
6.5 | IC50 | 22 | — | |
UCEQXRCJXIVODC
|
6.5 | Ki | 4 | — | |
MJSHVHLADKXCML
|
6.4 | IC50 | 11 | — | |
QZFNZRUAGFFIGB
|
6.4 | pIC50 | 2 | Yes | |
KFDMABXQUQMQTQ
|
6.4 | IC50 | 3 | — | |
AJHJEQWEJUXGIF
|
6.4 | IC50 | 4 | — | |
BDTVSYMIPDPQBV
|
6.4 | IC50 | 5 | — | |
FUGPVNRCNPSEKE
|
6.4 | IC50 | 2 | — | |
GYQWOGHOBIBGDV
|
6.4 | IC50 | 4 | — | |
NDRHTROVESKHSY
|
6.4 | IC50 | 2 | — | |
RZUOCXOYPYGSKL
|
6.4 | Kd | 8 | — | |
TZFAMUMVJZGJNK
|
6.4 | IC50 | 2 | — | |
XXBBUXMASYVMBJ
|
6.4 | IC50 | 2 | — | |
ATUIHXRIJCYLPA
|
6.4 | IC50 | 4 | — | |
CXFLFTVIZRBMKT
|
6.4 | IC50 | 2 | — | |
DOTUMOAINSRLGC
|
6.4 | IC50 | 2 | — | |
GSXRCPJTNIGKSZ
|
6.4 | Ki | 43 | — | |
ILUGAYBMBIJXHC
|
6.4 | Ki | 9 | — | |
JWQOJVOKBAAAAR
|
6.4 | Ki | 29 | — | |
LGHBDVLAHHANMX
|
6.4 | Ki | 53 | — | |
LYNBNVBMAGDJRW
|
6.4 | Ki | 81 | — | |
PKCDDUHJAFVJJB
|
6.4 | Kd | 13 | — | |
WAKGEHXTOOFEAE
|
6.4 | Ki | 27 | — | |
WVYHFPSGWCCXMO
|
6.4 | IC50 | 5 | — | |
YEPNVBNYCRGZRX
|
6.4 | Ki | 26 | — | |
BIQJCRVAKMGXKP
|
6.4 | IC50 | 2 | — | |
LYADGAGFYYXXIO
|
6.4 | IC50 | 82 | — | |
AKWLDQDWZNJYKL
|
6.4 | IC50 | 14 | — | |
SSKKUDJZPQHMHO
|
6.4 | IC50 | 2 | — | |
KVPNOQAXVUMKFJ
|
6.4 | IC50 | 3 | Yes | |
XQLXHIGCGPBKTR
|
6.4 | Kd | 5 | — | |
HVZHUYCJAOSSBB
|
6.3 | IC50 | 2 | — | |
UORMFDMJXVPCKX
|
6.3 | IC50 | 2 | — | |
NHEOMGKMIVQQIX
|
6.3 | IC50 | 4 | — | |
GGVWIGDCUUVFSZ
|
6.3 | IC50 | 4 | — | |
CKVWQORGCCEYHS
|
6.3 | Ki | 50 | — | |
FAYAUAZLLLJJGH
|
6.3 | Ki | 36 | Yes |