Target Details
| UniProt AC | P08581 |
|---|---|
| Gene Symbol | MET |
| Protein Name | Hepatocyte growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF01437 (PSI) PF01403 (Sema) PF01833 (TIG) |
Summary
- Multi-target molecules 1,125
- Clinical molecules 162
- Avg pChEMBL 7.37
KEGG Pathways (25)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Transcriptional misregulation in cancer
Associated Diseases (8)
Active Molecules (1,125)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WYRLDZNQPSAQEB
|
6.6 | IC50 | 2 | — | |
ACRSYDLSAYZZOB
|
6.6 | IC50 | 2 | — | |
AFULKBCSARRLGA
|
6.6 | IC50 | 2 | — | |
APAZLBBJADULHZ
|
6.6 | IC50 | 3 | — | |
GHWWKCOVVBFNIP
|
6.6 | IC50 | 2 | — | |
JBRASADWXDKCLJ
|
6.6 | Ki | 22 | — | |
LJKJYKWDLJUZHA
|
6.6 | Ki | 24 | — | |
MULNSLQVKKUPJN
|
6.6 | Ki | 41 | — | |
MZDKLVOWGIOKTN
|
6.6 | Ki | 80 | — | |
NRZYTPAJGVTKIM
|
6.6 | Ki | 38 | — | |
OBHMNLIBIPFXCY
|
6.6 | Ki | 15 | — | |
OJUUSOUIONBYQX
|
6.6 | IC50 | 2 | — | |
QONPPIZSNSSCSK
|
6.6 | Ki | 45 | Yes | |
XTVULKIROSNNTG
|
6.6 | Ki | 29 | — | |
FHDPQTHZTKXVCW
|
6.6 | pIC50 | 8 | Yes | |
UIARLYUEJFELEN
|
6.6 | Kd | 289 | Yes | |
ODPGGGTTYSGTGO
|
6.6 | Kd | 153 | — | |
RFJYJWFDGPUVNO
|
6.6 | IC50 | 2 | — | |
VERWOWGGCGHDQE
|
6.6 | IC50 | 23 | — | |
FKJJTKYQXXLFPS
|
6.6 | IC50 | 2 | — | |
FQDAGUFKVOIFKE
|
6.6 | IC50 | 2 | — | |
GVWDYJCKQRURCQ
|
6.6 | IC50 | 3 | — | |
HDEOUPSYLGQVJQ
|
6.6 | IC50 | 2 | — | |
IPPTWJWXDUGTIB
|
6.6 | IC50 | 3 | — | |
JBJWFWHCJNZJRH
|
6.6 | IC50 | 2 | — | |
KFEFKIWJIUXWLM
|
6.6 | IC50 | 2 | — | |
LDEFLKJREPNDBI
|
6.6 | IC50 | 2 | — | |
LODCEWAGOSUPNZ
|
6.6 | IC50 | 2 | — | |
PQJZMCSRHABDJY
|
6.6 | IC50 | 2 | — | |
QBPHXRDBFFVSQC
|
6.6 | IC50 | 2 | — | |
QZXMHSSMITURNJ
|
6.6 | IC50 | 2 | — | |
UGLZXRPFZYUMAE
|
6.6 | IC50 | 2 | — | |
WZOFSMBEVPAWHX
|
6.6 | IC50 | 2 | — | |
YIXKAKWRCBZYNE
|
6.6 | IC50 | 2 | — | |
YZXPXXZCCJVPRH
|
6.6 | IC50 | 3 | — | |
NHHQJBCNYHBUSI
|
6.5 | Kd | 220 | — | |
YUUSZYOOPDARLV
|
6.5 | IC50 | 2 | — | |
ATOVGFGJTVTJSL
|
6.5 | IC50 | 2 | — | |
FEQNECCIEFZWKT
|
6.5 | IC50 | 2 | — | |
HPOOZLXEYDPHFI
|
6.5 | IC50 | 3 | — | |
BULVKSWQYNUHHB
|
6.5 | IC50 | 2 | — | |
KHJCRDAQJTVGIC
|
6.5 | IC50 | 2 | — | |
KVVWSWZRLJGEJZ
|
6.5 | IC50 | 2 | — | |
CZVVMRNEBRFYTL
|
6.5 | pIC50 | 9 | Yes | |
HDRLAVNNWSHSOA
|
6.5 | Ki | 19 | — | |
JXNMCDLXYWQTIW
|
6.5 | Ki | 13 | — | |
KKYPRNBBPBRJQX
|
6.5 | Ki | 40 | — | |
LLGFEJJPLZCCQL
|
6.5 | pIC50 | 10 | Yes | |
LVECPYVAIBNSRV
|
6.5 | Ki | 33 | — | |
MQRDVGBWWVWMEN
|
6.5 | Ki | 47 | — |