Target Details
| UniProt AC | P08581 |
|---|---|
| Gene Symbol | MET |
| Protein Name | Hepatocyte growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF01437 (PSI) PF01403 (Sema) PF01833 (TIG) |
Summary
- Multi-target molecules 1,125
- Clinical molecules 162
- Avg pChEMBL 7.37
KEGG Pathways (25)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Transcriptional misregulation in cancer
Associated Diseases (8)
Active Molecules (1,125)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DLWMVUDMPMKGEE
|
6.9 | Ki | 24 | — | |
GJKVMXDBPDDFHI
|
6.9 | Ki | 27 | — | |
JAMDNXUAYUHJLJ
|
6.9 | Ki | 40 | — | |
JENNUAZOMOUEKD
|
6.9 | pIC50 | 2 | Yes | |
OOMBFNDWQIGHEK
|
6.9 | IC50 | 22 | — | |
OWCRGMTXRLQPSC
|
6.9 | IC50 | 2 | — | |
QVNZKVACBBTKSL
|
6.9 | Ki | 38 | — | |
XJSFDMGICAWQFS
|
6.9 | Ki | 60 | — | |
ZIZAGKWTJFKACS
|
6.9 | IC50 | 2 | — | |
BLQJPEQBTMZVKM
|
6.9 | IC50 | 2 | — | |
DYBYBSJVJPDSSC
|
6.9 | IC50 | 2 | — | |
OYUDNKFIGXAIRZ
|
6.9 | pIC50 | 16 | Yes | |
WDJUUISIVREQHL
|
6.9 | pIC50 | 6 | Yes | |
BHSQJJXTIHCAAO
|
6.9 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
6.9 | IC50 | 408 | — | |
VZXLODFBDTXBJK
|
6.9 | IC50 | 2 | — | |
MVMGHPHRNLHXAW
|
6.9 | IC50 | 2 | — | |
RLAJOHAIIACFAM
|
6.8 | pIC50 | 13 | Yes | |
VSJXTUFWPAOYLC
|
6.8 | pIC50 | 11 | Yes | |
DCMKAPVKXJVEOA
|
6.8 | IC50 | 2 | — | |
PZRVIBIFSSVDAU
|
6.8 | IC50 | 2 | — | |
QGVMEYLFVOBUHE
|
6.8 | IC50 | 2 | — | |
AVYOLAXEGQHYJJ
|
6.8 | IC50 | 2 | — | |
BDVGHJLTQZVVPA
|
6.8 | IC50 | 2 | — | |
GUGPWGWLXMBBBT
|
6.8 | pIC50 | 2 | Yes | |
MBXGLXVDXHVTCF
|
6.8 | IC50 | 2 | — | |
NKANTOLWUPJONB
|
6.8 | IC50 | 2 | — | |
SYXAZEFBEOQPCZ
|
6.8 | Kd | 3 | — | |
USIBAYBVISAAME
|
6.8 | IC50 | 2 | — | |
XOCLVVBZUKTGHF
|
6.8 | IC50 | 5 | — | |
MCCRETZLJIMVSF
|
6.8 | IC50 | 2 | — | |
DIWRJVJHXXZINL
|
6.8 | IC50 | 4 | — | |
IFPPYSWJNWHOLQ
|
6.8 | Ki | 52 | Yes | |
MWCJYALAMCYPDD
|
6.8 | IC50 | 2 | — | |
RDEKYROQCDTNPC
|
6.8 | IC50 | 2 | — | |
ULXXDDBFHOBEHA
|
6.8 | Kd | 15 | Yes | |
YMIJUBCSOKSFRU
|
6.8 | Ki | 87 | — | |
LNDWTKJDTCDSMV
|
6.8 | IC50 | 2 | — | |
VGPUSZSVCBVTBJ
|
6.8 | IC50 | 2 | — | |
CFVOAVDAPUQRNK
|
6.8 | IC50 | 5 | Yes | |
JQCFDXGKRBRABG
|
6.8 | IC50 | 2 | — | |
NDJFHTJMWGADJW
|
6.8 | IC50 | 2 | — | |
QKKIWEILHCXECO
|
6.8 | IC50 | 24 | — | |
WVXNSAVVKYZVOE
|
6.8 | IC50 | 92 | — | |
BPZWKCFQGZOCKL
|
6.7 | IC50 | 2 | — | |
JVNNQMKXIIVSCG
|
6.7 | IC50 | 2 | — | |
ZGIZCVACDOOTHQ
|
6.7 | IC50 | 2 | — | |
SWODSVHOTLARGG
|
6.7 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
6.7 | Kd | 213 | — | |
ADLRDDWBCKMWCY
|
6.7 | IC50 | 3 | — |