Target Details
| UniProt AC | P08581 |
|---|---|
| Gene Symbol | MET |
| Protein Name | Hepatocyte growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF01437 (PSI) PF01403 (Sema) PF01833 (TIG) |
Summary
- Multi-target molecules 1,125
- Clinical molecules 162
- Avg pChEMBL 7.37
KEGG Pathways (25)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Transcriptional misregulation in cancer
Associated Diseases (8)
Active Molecules (1,125)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JFRXDVGOZQPQTN
|
7.1 | IC50 | 2 | — | |
KTEIFNKAUNYNJU
|
7.1 | Kd | 6 | Yes | |
NLOGXCAMKYLWJP
|
7.1 | IC50 | 2 | — | |
OEVGHYJRUBAZDE
|
7.1 | IC50 | 2 | — | |
XKZINYYXWJEYEL
|
7.1 | Ki | 37 | — | |
HQVWTQMEFOONTI
|
7.1 | IC50 | 2 | — | |
AWZFCQRICMFIES
|
7.1 | IC50 | 9 | Yes | |
VGEDWONGQUXJQA
|
7.1 | IC50 | 7 | — | |
DDYSIXDGDGDTAO
|
7.0 | pIC50 | 2 | Yes | |
HWTXIWLPSDZEKV
|
7.0 | pIC50 | 2 | Yes | |
MZTUKIVBKFNLSN
|
7.0 | IC50 | 2 | — | |
XZGHBUBWVBSIGX
|
7.0 | IC50 | 2 | — | |
APPXQUDJLJXULP
|
7.0 | IC50 | 47 | — | |
ZUPSCXXPAQXDAQ
|
7.0 | IC50 | 2 | — | |
ASUGUQWIHMTFJL
|
7.0 | Kd | 18 | — | |
VQGHLFSTBDILLT
|
7.0 | pIC50 | 2 | Yes | |
ZMRNBDZNIGVVOB
|
7.0 | IC50 | 2 | — | |
LLYDHPYAMNHNIM
|
7.0 | IC50 | 2 | — | |
MYRCTKCEUUSBDZ
|
7.0 | IC50 | 2 | — | |
OSZVHJYNXBUVAH
|
7.0 | IC50 | 12 | — | |
MGGANBWHQUWTFD
|
7.0 | IC50 | 3 | — | |
HKZKELVPGXJIMW
|
7.0 | Ki | 41 | — | |
UIRCQOKSJDLYBB
|
7.0 | Ki | 50 | — | |
UTVRIBMVWAZOJP
|
7.0 | IC50 | 2 | — | |
XAHJIRNRDAKTEF
|
7.0 | Ki | 18 | — | |
ZTBLGRHKLBXAEK
|
7.0 | IC50 | 2 | — | |
ZWVZORIKUNOTCS
|
7.0 | pIC50 | 10 | Yes | |
FJSAYHJPHADVOT
|
7.0 | IC50 | 2 | — | |
ZJDFSKSBQBPOSK
|
7.0 | pIC50 | 24 | Yes | |
HKSZLNNOFSGOKW
|
7.0 | IC50 | 118 | — | |
SEKBRVIHGSJFOQ
|
7.0 | IC50 | 2 | — | |
BXBIAORMFZJTAV
|
7.0 | IC50 | 2 | — | |
KCGZBCPPQUZSHH
|
7.0 | IC50 | 2 | — | |
QCLJQTOGBRCCMK
|
7.0 | IC50 | 2 | — | |
RPQMDMNGSVDNRE
|
7.0 | IC50 | 2 | — | |
XLYVQVWMTOLDNL
|
7.0 | IC50 | 21 | — | |
XLYVQVWMTOLDNL
|
7.0 | IC50 | 21 | — | |
OBFSYIGNFLQCLK
|
7.0 | pIC50 | 2 | Yes | |
SLZAEQKODIKXMS
|
7.0 | IC50 | 3 | — | |
VWELCPLMPPEKOL
|
7.0 | pIC50 | 9 | Yes | |
XLCWUIJQDPUYAW
|
7.0 | IC50 | 2 | — | |
NXEYJEPOEMMBPI
|
6.9 | IC50 | 2 | — | |
UWWKEGWAWVKCPF
|
6.9 | IC50 | 2 | — | |
AJBIYXUNQZYBRC
|
6.9 | IC50 | 3 | — | |
DEIJESKINOLXTC
|
6.9 | IC50 | 2 | — | |
FJMLHLTVDMXQCW
|
6.9 | IC50 | 2 | — | |
HAPYOEZQKCQEPE
|
6.9 | IC50 | 2 | — | |
JFJBQYDTDVUFOI
|
6.9 | IC50 | 3 | — | |
LYXOBSREVZDKST
|
6.9 | IC50 | 9 | — | |
CQBBMNXXVMOFCA
|
6.9 | Ki | 39 | — |