Target Details
| UniProt AC | P08581 |
|---|---|
| Gene Symbol | MET |
| Protein Name | Hepatocyte growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF01437 (PSI) PF01403 (Sema) PF01833 (TIG) |
Summary
- Multi-target molecules 1,125
- Clinical molecules 162
- Avg pChEMBL 7.37
KEGG Pathways (25)
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- EGFR tyrosine kinase inhibitor resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Focal adhesion
- Gastric cancer
- Hepatocellular carcinoma
- Integrin signaling
- MAPK signaling pathway
- Malaria
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Transcriptional misregulation in cancer
Associated Diseases (8)
Active Molecules (1,125)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WUBFAXNVDMCVIO
|
10.5 | pIC50 | 12 | Yes | |
FIRJXFZIOPYNKD
|
9.7 | IC50 | 2 | — | |
YULUVWHIOGBTPX
|
9.7 | pIC50 | 4 | Yes | |
CICHSTJOLCRZKB
|
9.7 | Kd | 2 | — | |
PZKGSVYNVAEKGQ
|
9.6 | IC50 | 2 | — | |
QJXVLXFGOHGSRH
|
9.4 | IC50 | 2 | — | |
CEIYRBYXRSULDG
|
9.3 | pIC50 | 4 | Yes | |
ODYPDMJDOCOPAV
|
9.3 | Kd | 2 | — | |
RNHWXYKRVZUXGO
|
9.3 | pIC50 | 4 | Yes | |
UUDPUQDMSHQSKH
|
9.3 | IC50 | 3 | — | |
CPSLMXLQONGQGR
|
9.3 | IC50 | 2 | — | |
VLBZFDFQVGAJSP
|
9.3 | IC50 | 2 | — | |
FDCKDXZISZRERO
|
9.2 | IC50 | 5 | — | |
PKFMTQRFZPFQOL
|
9.2 | pIC50 | 4 | Yes | |
WXYGIDYHRYBZIF
|
9.2 | IC50 | 2 | — | |
ONPGOSVDVDPBCY
|
9.2 | IC50 | 2 | — | |
IEQYRWPMNVPDLX
|
9.2 | IC50 | 2 | — | |
MGHILXJDAYVODV
|
9.2 | IC50 | 2 | — | |
SHDSJLJOOCLKPW
|
9.2 | IC50 | 2 | — | |
UHZVQVQDXDCANZ
|
9.1 | IC50 | 2 | — | |
TXHCXRCHSIVMSN
|
9.1 | IC50 | 3 | — | |
CCASRZWPCOLUMW
|
9.1 | IC50 | 3 | — | |
FNVQWFPDIYQCSF
|
9.1 | pIC50 | 8 | Yes | |
QODZCSPDZVDCSD
|
9.1 | IC50 | 7 | — | |
RSIRXFZBWSKWOR
|
9.1 | IC50 | 3 | — | |
JIYPGFPFAVEPFX
|
9.0 | IC50 | 2 | — | |
LJWVFWLHDDCALO
|
9.0 | IC50 | 3 | — | |
DORMVCLDXDMKMM
|
9.0 | IC50 | 2 | — | |
QAGVTWHQXWRSFS
|
9.0 | IC50 | 2 | — | |
AREYWCZYVPSHGS
|
9.0 | IC50 | 5 | — | |
DJNWXYTWORPJNI
|
9.0 | pIC50 | 4 | Yes | |
LXBUSRPKZONHPE
|
9.0 | pIC50 | 4 | Yes | |
MQRYORPEARKGSY
|
9.0 | pIC50 | 4 | Yes | |
OHLUERTUZNIQEE
|
9.0 | IC50 | 3 | — | |
OQKMFDJSKWESCR
|
9.0 | pIC50 | 4 | Yes | |
OZRNZXPMNJNRPE
|
9.0 | IC50 | 2 | — | |
QATOHKJFHXOHIB
|
9.0 | pIC50 | 2 | Yes | |
QQANYCOFSUVVIT
|
9.0 | IC50 | 3 | — | |
SBLMCLDRWJNEJK
|
9.0 | IC50 | 17 | — | |
SEJGTFPOEJWEGG
|
9.0 | Kd | 149 | — | |
VCBGNDQGKNIBBK
|
9.0 | pIC50 | 6 | Yes | |
VKIVUAVVIMZCSX
|
9.0 | IC50 | 2 | — | |
XBINIPRQWSOQIE
|
9.0 | pIC50 | 4 | Yes | |
ZKVQZKJTCLSERL
|
9.0 | pIC50 | 2 | Yes | |
ZMZOKLZTXMCMNW
|
9.0 | IC50 | 4 | — | |
UZISGDYRMAXEPZ
|
9.0 | IC50 | 5 | — | |
MINABFBKQMEGEQ
|
9.0 | IC50 | 3 | — | |
OBFGRWOUNPRHNH
|
9.0 | IC50 | 6 | — | |
SJSWLZFLXRBNSJ
|
9.0 | IC50 | 5 | — | |
NETRMZMGTHLSBM
|
8.9 | IC50 | 3 | — |