Target Details
| UniProt AC | P08263 |
|---|---|
| Gene Symbol | GSTA1 |
| Protein Name | Glutathione S-transferase A1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00043 (GST_C) PF02798 (GST_N) |
Summary
- Multi-target molecules 9
- Clinical molecules 0
- Avg pChEMBL 7.13
KEGG Pathways (12)
- Chemical carcinogenesis - DNA adducts
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Drug metabolism - cytochrome P450
- Drug metabolism - other enzymes
- Fluid shear stress and atherosclerosis
- Glutathione metabolism
- Hepatocellular carcinoma
- Metabolic pathways
- Metabolism of xenobiotics by cytochrome P450
- Pathways in cancer
- Platinum drug resistance
Top Co-occurrence Targets
- GSTP1 9 shared
Active Molecules (9)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YEMUCFZFKLJIET
|
7.8 | IC50 | 2 | — | |
FGDHVUMZJFNQIL
|
7.6 | IC50 | 2 | — | |
QONBNYTUVRQCDJ
|
7.5 | IC50 | 2 | — | |
KEFKIIFBLWDSKC
|
7.4 | IC50 | 2 | — | |
UQYZKFCWWOEUOK
|
7.3 | IC50 | 2 | — | |
ZEZQAPSIRNZFJU
|
7.0 | IC50 | 2 | — | |
GJHAXLHKYOVJBX
|
6.7 | IC50 | 2 | — | |
JDNMAGZNSICFGF
|
6.5 | IC50 | 2 | — | |
GBJJMLCSNHLVQI
|
6.4 | IC50 | 2 | — |