Target Details
| UniProt AC | P08069 |
|---|---|
| Gene Symbol | IGF1R |
| Protein Name | Insulin-like growth factor 1 receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 611
- Clinical molecules 120
- Avg pChEMBL 7.78
KEGG Pathways (32)
- AMPK signaling pathway
- Adherens junction
- Autophagy - animal
- Breast cancer
- Cadherin signaling
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Focal adhesion
- FoxO signaling pathway
- Glioma
- HIF-1 signaling pathway
- Hepatocellular carcinoma
- Hormone signaling
- Integrin signaling
- Long-term depression
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanoma
- Oocyte meiosis
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Progesterone-mediated oocyte maturation
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Transcriptional misregulation in cancer
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (611)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VUVAXIBXIAPBBM
|
7.5 | IC50 | 2 | — | |
BUKHWHCWUHMPKB
|
7.5 | Ki | 3 | — | |
KYODHQKKLBGUED
|
7.5 | IC50 | 3 | — | |
MVJMMLFMPWITEJ
|
7.5 | Ki | 110 | — | |
NKJTYXXPGXIGTL
|
7.5 | IC50 | 2 | — | |
VTRPSKIFOIGMRA
|
7.5 | IC50 | 3 | Yes | |
NYPPEWQPHYILTM
|
7.5 | IC50 | 2 | Yes | |
HEBKCUAEAWNUQL
|
7.5 | IC50 | 2 | — | |
OGBBOXLWGHVVPQ
|
7.5 | IC50 | 3 | — | |
VWELCPLMPPEKOL
|
7.5 | IC50 | 9 | Yes | |
HKSZLNNOFSGOKW
|
7.5 | IC50 | 49 | Yes | |
HHXONKYVQVDMAS
|
7.4 | IC50 | 3 | — | |
HKGJCZLDFIJHIO
|
7.4 | Ki | 2 | — | |
DZHMNRMMNFEUNL
|
7.4 | IC50 | 4 | Yes | |
MTUYBYGTWUVARZ
|
7.4 | IC50 | 2 | — | |
XWUXNFBFVBWTFY
|
7.4 | IC50 | 2 | — | |
GVBSYPNRBBBGNI
|
7.4 | IC50 | 2 | — | |
ZRFJCNOHKKQRSS
|
7.4 | IC50 | 3 | — | |
BJSZKHZJEOKFJO
|
7.4 | IC50 | 4 | Yes | |
FXDWNCFVVOSWKM
|
7.4 | IC50 | 5 | Yes | |
IXIJKXSIADDKHR
|
7.4 | IC50 | 12 | — | |
MHMZAQRFOMCIRZ
|
7.4 | IC50 | 3 | Yes | |
WCIIYKWDVLHGIY
|
7.4 | IC50 | 2 | — | |
CGJRRFJDMMUHJW
|
7.4 | IC50 | 5 | Yes | |
APLSHXFBXOJEDP
|
7.4 | IC50 | 2 | — | |
HAJVSTFCLZBFNA
|
7.4 | IC50 | 3 | Yes | |
HKSZLNNOFSGOKW
|
7.4 | IC50 | 118 | — | |
PKCDDUHJAFVJJB
|
7.4 | Kd | 13 | — | |
AILRADAXUVEEIR
|
7.4 | IC50 | 75 | — | |
QAXSZRIWQDFFMT
|
7.4 | Ki | 2 | — | |
ZKSMNJVVPOADIE
|
7.4 | IC50 | 3 | — | |
QSLMZWGPJXKPBS
|
7.4 | IC50 | 3 | — | |
ANBSWCCVJMJABF
|
7.3 | IC50 | 2 | — | |
OMEGCBMNQDIBMF
|
7.3 | IC50 | 2 | — | |
PAFOOYBINUNMGT
|
7.3 | IC50 | 6 | Yes | |
XBAUQTADQOFONU
|
7.3 | IC50 | 3 | — | |
JPSXZEQQHPNTNX
|
7.3 | IC50 | 5 | Yes | |
JVFLXTNKVBOVBS
|
7.3 | IC50 | 2 | — | |
LYOCYPVMXHFJAK
|
7.3 | IC50 | 2 | — | |
SWDUUFOEGXYQAO
|
7.3 | IC50 | 3 | — | |
DGKDQGNOYZSJDK
|
7.3 | IC50 | 2 | — | |
RRXVMGHOCPACNG
|
7.3 | IC50 | 6 | Yes | |
VVICOEQHILEAPE
|
7.3 | IC50 | 2 | — | |
AXHWESODWDIJCC
|
7.3 | IC50 | 2 | — | |
GULNVBIIVHJZFA
|
7.3 | IC50 | 3 | Yes | |
KCSXXVMVRJMJFA
|
7.3 | IC50 | 2 | — | |
OOBAQMLMJUYICG
|
7.3 | IC50 | 2 | — | |
RDNOLDWOMGZBPI
|
7.3 | IC50 | 8 | Yes | |
RYYNGWLOYLRZLK
|
7.3 | Ki | 104 | — | |
SKSUFRGHAZAZHS
|
7.3 | IC50 | 2 | — |