Target Details
| UniProt AC | P08069 |
|---|---|
| Gene Symbol | IGF1R |
| Protein Name | Insulin-like growth factor 1 receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 611
- Clinical molecules 120
- Avg pChEMBL 7.78
KEGG Pathways (32)
- AMPK signaling pathway
- Adherens junction
- Autophagy - animal
- Breast cancer
- Cadherin signaling
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Focal adhesion
- FoxO signaling pathway
- Glioma
- HIF-1 signaling pathway
- Hepatocellular carcinoma
- Hormone signaling
- Integrin signaling
- Long-term depression
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanoma
- Oocyte meiosis
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Progesterone-mediated oocyte maturation
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Transcriptional misregulation in cancer
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (611)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IRAGSKPXCRLVGU
|
8.4 | IC50 | 2 | Yes | |
IZHDXWHHMHQBQI
|
8.4 | IC50 | 3 | — | |
NFMGZVPRGVERNN
|
8.4 | Ki | 44 | — | |
QMOJTBYMFQXLLU
|
8.4 | IC50 | 6 | Yes | |
CPFRXSGEPFEUFG
|
8.3 | IC50 | 2 | — | |
HGXOLSAJHMUDJP
|
8.3 | IC50 | 2 | — | |
MCHOTIIDAJHLED
|
8.3 | IC50 | 5 | Yes | |
OWRXHGAFWZFFCW
|
8.3 | Ki | 113 | — | |
RNIDGDNODCTPSJ
|
8.3 | IC50 | 2 | — | |
HMXWMMRCKSDFCV
|
8.3 | IC50 | 10 | Yes | |
UBHVSGGXYKHEIW
|
8.3 | IC50 | 3 | Yes | |
GURLMHMMTNQPMF
|
8.2 | IC50 | 3 | Yes | |
HZGCLKXERMMKEB
|
8.2 | IC50 | 2 | Yes | |
IEPKZTQXMCCRFJ
|
8.2 | IC50 | 4 | — | |
RGGGQYILVSQJDN
|
8.2 | IC50 | 3 | Yes | |
VEKQRWMLMKCRSW
|
8.2 | IC50 | 3 | Yes | |
IDRQGRCXNROMMS
|
8.2 | IC50 | 3 | — | |
IHRFTDHYCNWNFR
|
8.2 | IC50 | 3 | — | |
FHDPQTHZTKXVCW
|
8.2 | IC50 | 8 | Yes | |
HZTYDQRUAWIZRE
|
8.2 | IC50 | 40 | Yes | |
NBRHHKSETRXRCP
|
8.2 | IC50 | 2 | — | |
SKFDSQFYKXYVPS
|
8.2 | IC50 | 9 | Yes | |
XGZORHKVFKUMAV
|
8.2 | IC50 | 4 | — | |
XMJRRSFVUFDVMT
|
8.2 | IC50 | 2 | — | |
SKBWQUPLWQUWPH
|
8.1 | IC50 | 6 | Yes | |
GVHNKGKLBRLAOO
|
8.1 | IC50 | 2 | — | |
LQRGRVAYEDLPTG
|
8.1 | IC50 | 3 | Yes | |
QSIOQQCLBORXLE
|
8.1 | IC50 | 3 | Yes | |
IWKVFBINMMDGNH
|
8.1 | IC50 | 3 | — | |
DRYWSMFQHZVTJK
|
8.1 | IC50 | 3 | — | |
GYHFAWCGOCYIPE
|
8.1 | IC50 | 2 | — | |
BCTIPSBBPQBXAG
|
8.1 | IC50 | 4 | — | |
QDVKRHSEGADNGG
|
8.1 | IC50 | 5 | Yes | |
XSBPOCYYAOOLIV
|
8.1 | IC50 | 2 | — | |
UJVYDMJHGODRML
|
8.0 | IC50 | 2 | — | |
RLJRJTRUMLEXST
|
8.0 | IC50 | 2 | Yes | |
HIMUEIQDEDWCOT
|
8.0 | IC50 | 2 | — | |
HZSFGSOFGMHYMF
|
8.0 | IC50 | 2 | — | |
DLKLSEQEOIJHQF
|
7.9 | IC50 | 2 | — | |
ILEKZDZXDKJKKW
|
7.9 | IC50 | 2 | — | |
ZCCPLJOKGAACRT
|
7.9 | Kd | 599 | — | |
CFXKXVRFVROHAJ
|
7.9 | IC50 | 2 | — | |
HZSFGSOFGMHYMF
|
7.9 | IC50 | 2 | — | |
DLQXAWIVHRHOQT
|
7.9 | IC50 | 6 | Yes | |
CBCRRZVVZMJUTF
|
7.9 | IC50 | 3 | — | |
IHYLDWZRFWDOLG
|
7.9 | IC50 | 2 | Yes | |
MYPQGCUDQYBJLG
|
7.9 | IC50 | 3 | Yes | |
RPLGLPFQGFBRBL
|
7.9 | IC50 | 5 | Yes | |
VMSXLNMNMRCQPD
|
7.9 | IC50 | 3 | Yes | |
YDTUAGVDOJNKMO
|
7.9 | IC50 | 2 | Yes |