Target Details
| UniProt AC | P08069 |
|---|---|
| Gene Symbol | IGF1R |
| Protein Name | Insulin-like growth factor 1 receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 611
- Clinical molecules 120
- Avg pChEMBL 7.78
KEGG Pathways (32)
- AMPK signaling pathway
- Adherens junction
- Autophagy - animal
- Breast cancer
- Cadherin signaling
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Focal adhesion
- FoxO signaling pathway
- Glioma
- HIF-1 signaling pathway
- Hepatocellular carcinoma
- Hormone signaling
- Integrin signaling
- Long-term depression
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanoma
- Oocyte meiosis
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Progesterone-mediated oocyte maturation
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Transcriptional misregulation in cancer
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (611)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JLKHWWQNUUOAOS
|
6.2 | Ki | 2 | — | |
WXVJFRUQXJHDPY
|
6.2 | IC50 | 4 | Yes | |
ZJROCJVDMHFPBR
|
6.2 | IC50 | 4 | Yes | |
CFVOAVDAPUQRNK
|
6.2 | IC50 | 5 | Yes | |
OHLUERTUZNIQEE
|
6.2 | Ki | 3 | — | |
LBFSRNMRNQGAAI
|
6.2 | Ki | 3 | — | |
VFJQYKOAZFSECZ
|
6.2 | IC50 | 2 | — | |
LUAWSFFQLRPDPM
|
6.1 | Ki | 3 | — | |
OZNRQZFKHOJXCQ
|
6.1 | IC50 | 2 | — | |
YEQCPIHPQUSWMC
|
6.1 | IC50 | 5 | Yes | |
FWXODUHNWANOFN
|
6.1 | Ki | 3 | — | |
GCIKSSRWRFVXBI
|
6.1 | Kd | 109 | Yes | |
HYHNNPKOTNCPJU
|
6.1 | IC50 | 2 | — | |
OHLUERTUZNIQEE
|
6.1 | Ki | 3 | — | |
COPINYWCESNOFK
|
6.1 | IC50 | 3 | — | |
NMJMRSQTDLRCRQ
|
6.1 | IC50 | 7 | — | |
LOYHRPQPVDZCBA
|
6.1 | IC50 | 4 | — | |
ZYVXTMKTGDARKR
|
6.1 | IC50 | 6 | — | |
GBYYHFNOPGCXMC
|
6.1 | IC50 | 2 | — | |
JBMGNUFDDDRKSW
|
6.1 | IC50 | 6 | Yes | |
JRLSUZIPUYDUKX
|
6.1 | Ki | 22 | — | |
MZDKLVOWGIOKTN
|
6.1 | Ki | 80 | — | |
XMGFTZYNTYNOOJ
|
6.1 | Ki | 10 | — | |
ARSLABFLEJRETK
|
6.1 | IC50 | 3 | — | |
GEPKFPGFWUHVLZ
|
6.1 | IC50 | 6 | Yes | |
RWHWCXWOAWCNNW
|
6.1 | IC50 | 4 | Yes | |
IFTCXKUSJMWVRD
|
6.1 | IC50 | 7 | Yes | |
HLYLVLPUVNOQHH
|
6.1 | Ki | 3 | — | |
QSQLSTWOUFBPKW
|
6.1 | IC50 | 4 | — | |
VCMSULGORSGFSP
|
6.1 | Ki | 3 | — | |
GODJFMYOWZKKJA
|
6.0 | Ki | 2 | — | |
KDZRBSFVKQWODV
|
6.0 | Ki | 2 | — | |
UYMSIPINLJNNOU
|
6.0 | Ki | 4 | — | |
AROMUEFGOQGFHF
|
6.0 | Ki | 3 | — | |
JBRATJAZJLQBMD
|
6.0 | IC50 | 2 | — | |
LSEAQLOYCHTEOK
|
6.0 | IC50 | 10 | — | |
UULBQMUKTJCSOZ
|
6.0 | IC50 | 2 | — | |
YYLKKYCXAOBSRM
|
6.0 | Kd | 191 | — | |
HHKGVQGXRGQBBA
|
6.0 | IC50 | 4 | Yes | |
RYQBKVFFHMNFTM
|
6.0 | Ki | 3 | — | |
IBWQJAQFQVORMS
|
6.0 | Ki | 2 | — | |
KSIRCFGDZWDBAM
|
6.0 | IC50 | 2 | — | |
GWILIXWGRREEOE
|
6.0 | IC50 | 2 | Yes | |
DJUSDFVEBBYFFL
|
6.0 | Ki | 27 | — | |
GLBZSOQDAOLMGC
|
6.0 | IC50 | 23 | Yes | |
HJVFTUSVRMGBLM
|
6.0 | IC50 | 7 | — | |
HZPACYSNLOCDLW
|
6.0 | Ki | 48 | — | |
IBPSHHSPUPWXHN
|
6.0 | Ki | 6 | — | |
IOBVCHJTLVPPBR
|
6.0 | Ki | 39 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — |