Target Details
| UniProt AC | P08069 |
|---|---|
| Gene Symbol | IGF1R |
| Protein Name | Insulin-like growth factor 1 receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 611
- Clinical molecules 120
- Avg pChEMBL 7.78
KEGG Pathways (32)
- AMPK signaling pathway
- Adherens junction
- Autophagy - animal
- Breast cancer
- Cadherin signaling
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Focal adhesion
- FoxO signaling pathway
- Glioma
- HIF-1 signaling pathway
- Hepatocellular carcinoma
- Hormone signaling
- Integrin signaling
- Long-term depression
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanoma
- Oocyte meiosis
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Progesterone-mediated oocyte maturation
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Transcriptional misregulation in cancer
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (611)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZIPMVFDKNBGKAT
|
6.4 | IC50 | 3 | — | |
UHJXGMZSUQNCOU
|
6.4 | Ki | 4 | Yes | |
GLTRPHMPCVLOJS
|
6.4 | IC50 | 3 | — | |
QDOTUHIGOCRMSM
|
6.4 | IC50 | 3 | — | |
AEYLJTAIDDIOBA
|
6.4 | Ki | 53 | — | |
JCFJQIHDZHHMQT
|
6.4 | Ki | 42 | — | |
JNSMYVIVQDWCFM
|
6.4 | IC50 | 3 | — | |
NVRXTLZYXZNATH
|
6.4 | Ki | 47 | Yes | |
UGEJLCNSVIVALC
|
6.4 | Ki | 41 | — | |
UJBJWYNPUOLFIZ
|
6.4 | Ki | 49 | — | |
YMIJUBCSOKSFRU
|
6.4 | Ki | 87 | — | |
ZHTVWJDQZBBZHV
|
6.4 | Ki | 9 | — | |
BETBNWGUKZUUAX
|
6.4 | IC50 | 21 | — | |
QQANYCOFSUVVIT
|
6.4 | Ki | 3 | — | |
CXQHYVUVSFXTMY
|
6.4 | Kd | 154 | — | |
SEJGTFPOEJWEGG
|
6.4 | Kd | 149 | — | |
SGQJPPQXKVUHGS
|
6.4 | IC50 | 6 | Yes | |
PRUWBPAGUCKXMV
|
6.4 | IC50 | 2 | — | |
WGEGYCKWUWQOIP
|
6.4 | IC50 | 3 | — | |
IMXLKPSPRSVIRB
|
6.3 | IC50 | 4 | — | |
AFTBNZZMNUUEFO
|
6.3 | IC50 | 7 | — | |
KOZFSFOOLUUIGY
|
6.3 | IC50 | 26 | — | |
DJOJKIGNNDWGRS
|
6.3 | Ki | 13 | — | |
HDRLAVNNWSHSOA
|
6.3 | Ki | 19 | — | |
IPTSYCYNQJITNJ
|
6.3 | Ki | 12 | — | |
IZEZSPVHWUPXAH
|
6.3 | IC50 | 2 | — | |
JNXJKTXDSPWNRP
|
6.3 | Ki | 30 | — | |
LJKJYKWDLJUZHA
|
6.3 | Ki | 24 | — | |
PLSQYACXDKUYFC
|
6.3 | IC50 | 3 | — | |
PZZSEHAIVIYFLT
|
6.3 | IC50 | 2 | — | |
QBKUOOQFSVMDPB
|
6.3 | Ki | 31 | — | |
UEBUEWAMMXNGMS
|
6.3 | IC50 | 2 | — | |
VCFDMLBPASGZTP
|
6.3 | Ki | 38 | — | |
XJSFDMGICAWQFS
|
6.3 | Ki | 60 | — | |
ZBYGBITZFKOQTA
|
6.3 | Ki | 18 | — | |
QYHQSWFHKDOPJR
|
6.3 | IC50 | 3 | — | |
WPHKIQPVPYJNAX
|
6.3 | IC50 | 81 | — | |
XUFQDXFSMAAIGC
|
6.3 | Ki | 2 | — | |
GKQIKYWYJQQLLD
|
6.3 | IC50 | 3 | — | |
VLSRGLWQHNMOLJ
|
6.2 | Ki | 3 | — | |
GYCPBMYHPVDKFK
|
6.2 | Ki | 3 | — | |
YYQLLFCNZXWBJQ
|
6.2 | Ki | 4 | Yes | |
OKYKKFLCZPGQHI
|
6.2 | IC50 | 5 | — | |
RDTDWGQDFJPTPD
|
6.2 | IC50 | 6 | Yes | |
NJPZYQYDYUEVPF
|
6.2 | Ki | 3 | — | |
GXJSLIOOPZRPEV
|
6.2 | Ki | 34 | — | |
JPCWMTOYDYYXLS
|
6.2 | Ki | 7 | — | |
PAIFYAZSILXLBO
|
6.2 | Ki | 26 | — | |
WINHZLLDWRZWRT
|
6.2 | Ki | 66 | — | |
YMFWEIKNDBLHIR
|
6.2 | Ki | 3 | — |