Target Details
| UniProt AC | P08069 |
|---|---|
| Gene Symbol | IGF1R |
| Protein Name | Insulin-like growth factor 1 receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 611
- Clinical molecules 120
- Avg pChEMBL 7.78
KEGG Pathways (32)
- AMPK signaling pathway
- Adherens junction
- Autophagy - animal
- Breast cancer
- Cadherin signaling
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Focal adhesion
- FoxO signaling pathway
- Glioma
- HIF-1 signaling pathway
- Hepatocellular carcinoma
- Hormone signaling
- Integrin signaling
- Long-term depression
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanoma
- Oocyte meiosis
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Progesterone-mediated oocyte maturation
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Transcriptional misregulation in cancer
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (611)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
LYNBNVBMAGDJRW
|
6.8 | Ki | 81 | — | |
NCPXFACDZCEIQL
|
6.8 | Ki | 7 | — | |
XSRNXUBVNYNCJC
|
6.8 | IC50 | 2 | — | |
AZCHQQLGTDJHFL
|
6.8 | IC50 | 3 | — | |
HGZYVJNUFKTDLR
|
6.8 | IC50 | 2 | — | |
HGZYVJNUFKTDLR
|
6.8 | IC50 | 2 | — | |
PAFOOYBINUNMGT
|
6.8 | IC50 | 6 | Yes | |
QDKVMCOVHGDSAE
|
6.8 | IC50 | 2 | — | |
MINABFBKQMEGEQ
|
6.8 | Ki | 3 | — | |
TYYJYNQSJRUHFJ
|
6.7 | IC50 | 3 | — | |
WASNZPFVELUKFM
|
6.7 | IC50 | 2 | — | |
QPYYLLKCTPKJEO
|
6.7 | Ki | 3 | — | |
ALKJNCZNEOTEMP
|
6.7 | IC50 | 55 | — | |
DKMXEBIKMPYHST
|
6.7 | IC50 | 2 | — | |
HYCYVMNKZFALHN
|
6.7 | IC50 | 5 | — | |
GXKYSFQMTTZPGW
|
6.7 | Ki | 7 | — | |
JTRNNNVASYCTLO
|
6.7 | Ki | 14 | — | |
JZTOUVBEZONDKA
|
6.7 | Ki | 80 | — | |
LSFLAQVDISHMNB
|
6.7 | Ki | 13 | — | |
OTVCFDOYUHREFJ
|
6.7 | Ki | 26 | — | |
PROLIXHVRCJEFH
|
6.7 | Ki | 46 | — | |
GMAZSCDBFSDVRI
|
6.7 | IC50 | 3 | — | |
RPUSLEYUMRGACQ
|
6.7 | IC50 | 3 | — | |
HQZLQPMNIPRNBQ
|
6.7 | IC50 | 3 | — | |
AZFITEALNSCCOH
|
6.7 | IC50 | 2 | — | |
JEDCUDZEGIOLNY
|
6.7 | Ki | 2 | — | |
KTEIFNKAUNYNJU
|
6.7 | Ki | 48 | — | |
IHKWHSZSPBFQEP
|
6.6 | Ki | 3 | — | |
XSJJLTUTXVNLLI
|
6.6 | IC50 | 3 | — | |
BZWHAJVPFKNIQF
|
6.6 | Ki | 3 | — | |
LDXRJMINDNMMRX
|
6.6 | Ki | 3 | — | |
NFKMFNBKEOQNPZ
|
6.6 | Ki | 43 | — | |
RGNHKJWHFIPHIM
|
6.6 | Ki | 66 | — | |
CDIOXDOXJQDENS
|
6.6 | IC50 | 4 | Yes | |
HAYYBYPASCDWEQ
|
6.6 | IC50 | 47 | — | |
HXYIPFOMCPLBAX
|
6.6 | IC50 | 3 | — | |
LUCVGGOCKASWHT
|
6.6 | IC50 | 2 | — | |
JCKPXXCMARLTQI
|
6.5 | IC50 | 6 | Yes | |
VCDSHKSQYBUJEG
|
6.5 | Ki | 2 | — | |
FRHDZWLQTMKUPC
|
6.5 | IC50 | 11 | Yes | |
IWSFWGQTDDJZPR
|
6.5 | IC50 | 4 | Yes | |
QKKIWEILHCXECO
|
6.5 | IC50 | 24 | — | |
GCBJDOWIQHMCMR
|
6.5 | Ki | 84 | — | |
GNLAGGCSJGJECE
|
6.5 | Ki | 19 | Yes | |
QNZJDYVERIAXAI
|
6.5 | Ki | 7 | — | |
WNIMGBYJJBDBEY
|
6.5 | Ki | 2 | — | |
KTEIFNKAUNYNJU
|
6.5 | IC50 | 114 | — | |
NRBXSFVELYFYJD
|
6.5 | IC50 | 3 | Yes | |
CFVOAVDAPUQRNK
|
6.4 | IC50 | 4 | Yes | |
YBYZNVHZPUSHTD
|
6.4 | IC50 | 2 | — |