Target Details
| UniProt AC | P07382 |
|---|---|
| Gene Symbol | N/A |
| Protein Name | Bifunctional dihydrofolate reductase-thymidylate synthase |
| Organism | Leishmania major |
| Entry Name | |
| Organism Category | Pathogen |
| Pfam Domains | PF00186 (DHFR_1) PF00303 (Thymidylat_synt) |
Summary
- Multi-target molecules 31
- Clinical molecules 2
- Avg pChEMBL 6.75
Top Co-occurrence Targets
- DHFR 15 shared
- Tb08.26N11.790 13 shared
- PTR1 12 shared
- Tb07.10C21.550 8 shared
- folA 5 shared
- TYMS 2 shared
- thyA 2 shared
- NCOA3 1 shared
- SLC46A1 1 shared
- dfrA 1 shared
Active Molecules (31)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FBOZXECLQNJBKD
|
9.3 | IC50 | 16 | — | |
HRMBCMDDIJSWHA
|
8.4 | IC50 | 2 | — | |
YWYMUWNXZFMLTG
|
8.1 | IC50 | 2 | — | |
OYCWDHDJTHQWFU
|
7.7 | Ki | 3 | — | |
FBOZXECLQNJBKD
|
7.5 | IC50 | 4 | Yes | |
HLRBNCZMXWRQDR
|
7.2 | Ki | 2 | — | |
ZDOWVJFTJBBSAO
|
7.1 | Ki | 3 | — | |
LTKHPMDRMUCUEB
|
7.1 | Ki | 4 | Yes | |
UHGIVIFLYVOBQX
|
6.9 | IC50 | 3 | — | |
AMDVLSYFJVONRJ
|
6.8 | IC50 | 3 | — | |
HEPDQIIFCBFHRJ
|
6.8 | IC50 | 4 | — | |
XLIYQTRPSBVORD
|
6.7 | IC50 | 2 | — | |
CTNBRSFEBYDJGE
|
6.7 | IC50 | 2 | — | |
ASBJYAZYFSRQAB
|
6.6 | IC50 | 4 | — | |
OEBWFGZHAOVGKV
|
6.6 | IC50 | 2 | — | |
UKCFUFHREWUXJJ
|
6.6 | IC50 | 5 | — | |
HWBMRNZBDSXAMA
|
6.6 | Ki | 2 | — | |
RLZMSHCMNFJYHQ
|
6.4 | IC50 | 2 | — | |
OTZWZUHDCONCKN
|
6.3 | IC50 | 3 | — | |
UAAMNIQSVOHUSZ
|
6.3 | IC50 | 2 | — | |
BRALFIYXTYQKRH
|
6.2 | IC50 | 2 | — | |
NYNAFINLHQEHKU
|
6.2 | IC50 | 3 | — | |
ZWDTZORUEWRXEV
|
6.2 | Ki | 2 | — | |
FMBRAYUCAAUXJJ
|
6.2 | IC50 | 3 | — | |
URXOGQMRRPHSHR
|
6.1 | IC50 | 4 | — | |
IVBAHQCIRPVTSZ
|
6.1 | Kd | 2 | — | |
JFDMBYLFKZHPHM
|
6.1 | Ki | 2 | — | |
NKRKEQBTIYLTPA
|
6.1 | IC50 | 4 | — | |
RTTYEJCBYSIJNU
|
6.1 | IC50 | 2 | — | |
NQLDZGLJAMJTPQ
|
6.1 | IC50 | 3 | — | |
FGQMPGXSJKTERW
|
6.0 | IC50 | 3 | — |