Target Details
| UniProt AC | P06400 |
|---|---|
| Gene Symbol | RB1 |
| Protein Name | Retinoblastoma-associated protein |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF11934 (DUF3452) PF01858 (RB_A) PF01857 (RB_B) PF08934 (Rb_C) |
Summary
- Multi-target molecules 8
- Clinical molecules 3
- Avg pChEMBL 6.55
KEGG Pathways (25)
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Chemical carcinogenesis - receptor activation
- Chronic myeloid leukemia
- Cushing syndrome
- Endocrine resistance
- Epstein-Barr virus infection
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Kaposi sarcoma-associated herpesvirus infection
- Melanoma
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- Viral carcinogenesis
Associated Diseases (8)
Active Molecules (8)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HKSZLNNOFSGOKW
|
7.2 | IC50 | 408 | — | |
CFJGSVKNNIFWEA
|
6.7 | IC50 | 5 | Yes | |
CFJGSVKNNIFWEA
|
6.7 | IC50 | 3 | — | |
YWQFJBMWXOICTC
|
6.6 | IC50 | 8 | — | |
WYFUXDSMNLVNEA
|
6.4 | IC50 | 2 | — | |
WYFUXDSMNLVNEA
|
6.4 | IC50 | 4 | Yes | |
CUISPPCDYZFGCY
|
6.2 | IC50 | 2 | — | |
CUISPPCDYZFGCY
|
6.2 | IC50 | 4 | Yes |